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Urinary angiotensinogen as a biomarker for acute to chronic kidney injury transition - prognostic and mechanistic

Katie L Connor1, Laura Denby2

  • 1Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, U.K.

Clinical Science (London, England : 1979)
|November 15, 2018
PubMed

Insights

Urinary angiotensinogen (uAGT) may predict acute kidney injury (AKI) progression to chronic kidney disease (CKD). This biomarker could indicate renal recovery potential, guiding targeted interventions for kidney disease patients.

Area of Science:

  • Nephrology
  • Biomarker Discovery
  • Renal Medicine

Background:

  • Accurate biomarkers for predicting chronic kidney disease (CKD) progression and early detection are currently lacking.
  • This deficiency hinders the identification of individuals who could benefit from timely therapeutic interventions.
  • Urinary angiotensinogen (uAGT) is investigated as a potential predictive biomarker for kidney disease progression.

Purpose of the Study:

  • To evaluate the predictive capability of urinary angiotensinogen (uAGT) in forecasting the transition from acute kidney injury (AKI) to chronic kidney disease (CKD).
  • To assess uAGT as a dynamic marker of renal injury and its potential to predict structural recovery post-AKI.
  • To explore the clinical utility of uAGT and the potential of early renin-angiotensin system blockade as a therapeutic strategy following AKI.

Main Methods:

  • Utilized a murine model of ischemia-reperfusion injury to investigate uAGT's predictive potential.
  • Analyzed data from a small prospective study involving patients with biopsy-proven acute tubular necrosis.
  • Correlated uAGT levels with the progression of kidney injury and recovery outcomes.

Main Results:

  • Findings suggest uAGT serves as a dynamic indicator of renal injury.
  • uAGT may predict the likelihood of structural recovery after acute kidney injury.
  • The study provides preliminary evidence for uAGT's role in AKI-to-CKD transition prediction.

Conclusions:

  • Urinary angiotensinogen (uAGT) shows promise as a biomarker for predicting AKI to CKD progression.
  • uAGT may offer insights into renal recovery potential following AKI.
  • Further research is warranted to establish the clinical utility of uAGT and explore renin-angiotensin system blockade as a therapeutic target in AKI recovery.

Keywords:
AKICKDurinary biomarkers

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