Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nonlinear Pharmacokinetics: Michaelis-Menten Equation01:18

Nonlinear Pharmacokinetics: Michaelis-Menten Equation

1.1K
The Michaelis–Menten equation is a fundamental model for describing capacity-limited kinetics in drug metabolism. It offers insights into the rate of decline of plasma drug concentration Cp over time, with Vmax and KM as pivotal parameters.
Vmax represents the maximum achievable process rate, while KM, known as the Michaelis constant, signifies the drug concentration at which the process rate reaches half its maximum. This relationship between Vmax, KM, and Cp gives rise to three distinct...
1.1K
Determination of Michaelis Constant and Maximum Elimination Rate01:20

Determination of Michaelis Constant and Maximum Elimination Rate

475
The Michaelis constant (KM) and the theoretical maximum process rate (Vmax) are vital parameters in the Michaelis-Menten equation, central to many biochemical reactions. They provide essential insights into enzyme kinetics and drug metabolism.
These parameters can be estimated by analyzing plasma concentration data post-drug administration. A notable example of this application is phenytoin, a drug with capacity-limited kinetics. It's recommended that phenytoin should be administered at two...
475
Data Reporting and Recording01:24

Data Reporting and Recording

5.4K
Reporting and recording are crucial in data documentation. The timely, thorough, and accurate documentation of facts is essential when recording patient data. Failure to record findings during an assessment or interpretation of a problem will result in loss of information and make the patient document unreliable. The reader is left with general impressions if the information is not specific. A recording is documenting data of the individual's health information in a traceable, secure, and...
5.4K
Types of Reports I: Hands-off Report01:25

Types of Reports I: Hands-off Report

1.5K
A hand-off report, also known as a change-of-shift report, is a crucial nursing process that ensures the smooth transition of patient care responsibilities between nursing staff.
Following are the key components and categories of hand-off reports:
Purpose and Process:
1.5K
Types of Reports II: Incident or Occurrence Report01:21

Types of Reports II: Incident or Occurrence Report

1.3K
An Incident or Occurrence Report in a healthcare setting is a crucial document used to record any unexpected occurrence that may or may not have affected a patient, employee, or visitor. Such reports are critical to improving patient safety and include all details leading up to and including the event.
Purposes:
In the healthcare industry, reports play a crucial role in documenting incidents within an agency. The primary objective of these reports is to ensure patient safety, uphold the...
1.3K
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

636
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
636

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Heterozygous type 1 Autosomal Dominant Optic Atrophy (ADOA) with OPA1 c.1936-2A>G genetic variant.

Journal francais d'ophtalmologie·2020
Same author

Unnoticed implantation of a short XEN® device.

Journal francais d'ophtalmologie·2019
Same author

Axenfeld's anomaly.

Journal francais d'ophtalmologie·2019
Same author

Persistence of Descemet membrane and recipient-type endothelium after keratoplasty. A case report.

Archivos de la Sociedad Espanola de Oftalmologia·2019
Same author

Ocular external myiasis. A series of cases due to larvae Oestrus ovis in Navarra, Spain.

Archivos de la Sociedad Espanola de Oftalmologia·2018
Same author

Bilateral acute iris transillumination syndrome. A case report.

Archivos de la Sociedad Espanola de Oftalmologia·2018

Related Experiment Video

Updated: Feb 2, 2026

Conscious and Non-conscious Representations of Emotional Faces in Asperger's Syndrome
08:31

Conscious and Non-conscious Representations of Emotional Faces in Asperger's Syndrome

Published on: July 31, 2016

14.5K

[Michaelis-Manz syndrome. A case report].

P Plaza-Ramos1, L Tabuenca-Del Barrio, A Zubicoa-Eneriz

  • 1. pablo.plaza.ramos@alumni.unav.es.

Anales Del Sistema Sanitario De Navarra
|November 15, 2018
PubMed
Summary

Michaelis-Manz syndrome, a genetic kidney disorder, causes hypomagnesemia and hypercalciuria, potentially leading to kidney failure. This case highlights associated macular coloboma in an 18-year-old patient.

Area of Science:

  • Nephrology
  • Genetics
  • Ophthalmology

Background:

  • Michaelis-Manz syndrome is an autosomal recessive tubulopathy.
  • It involves mutations in claudin-16 and claudin-19 tight-junction proteins.
  • These proteins are crucial in kidney tubules and retinal pigment epithelium.

Observation:

  • The syndrome presents with hypomagnesemia, hypercalciuria, and nephrocalcinosis.
  • Renal failure is a significant prognostic factor.
  • Ophthalmological findings include macular coloboma, myopic staphyloma, and nystagmus.

Findings:

  • This report details an 18-year-old male with Michaelis-Manz syndrome.
  • The patient exhibited hereditary hypomagnesemia, hypercalciuria, and nephrocalcinosis.
  • He also presented with macular coloboma and maintained stable visual acuity.

More Related Videos

Robotic-assisted Left Pneumonectomy For Vanishing Lung Syndrome
07:27

Robotic-assisted Left Pneumonectomy For Vanishing Lung Syndrome

Published on: January 23, 2026

56
Portable Thermographic Screening for Detection of Acute Wallenberg's Syndrome
05:12

Portable Thermographic Screening for Detection of Acute Wallenberg's Syndrome

Published on: September 19, 2019

7.0K

Related Experiment Videos

Last Updated: Feb 2, 2026

Conscious and Non-conscious Representations of Emotional Faces in Asperger's Syndrome
08:31

Conscious and Non-conscious Representations of Emotional Faces in Asperger's Syndrome

Published on: July 31, 2016

14.5K
Robotic-assisted Left Pneumonectomy For Vanishing Lung Syndrome
07:27

Robotic-assisted Left Pneumonectomy For Vanishing Lung Syndrome

Published on: January 23, 2026

56
Portable Thermographic Screening for Detection of Acute Wallenberg's Syndrome
05:12

Portable Thermographic Screening for Detection of Acute Wallenberg's Syndrome

Published on: September 19, 2019

7.0K

Implications:

  • Understanding claudin mutations is key for diagnosing and managing this syndrome.
  • Early detection of renal and ocular manifestations is vital.
  • This case underscores the link between kidney function and vision in Michaelis-Manz syndrome.