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Related Experiment Videos

[Pathophysiologic principles of ventricular late potentials--mechanisms].

H Klein1, H J Trappe, E Schröder

  • 1Abteilung Kardiologie, Medizinische Hochschule Hannover.

Herz
|June 1, 1988
PubMed
Summary

Sustained ventricular tachycardias often result from reentry mechanisms. Abnormal electrograms, including fragmentation and double potentials, indicate delayed conduction and are larger in patients with ventricular tachycardia.

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Area of Science:

  • Electrophysiology
  • Cardiac Arrhythmia Mechanisms
  • Myocardial Tissue Alterations

Context:

  • Sustained ventricular tachycardias (VT) are primarily caused by reentry circuits.
  • Electrophysiological changes like conduction delay and block, stemming from myocardial scarring, ischemia, or fatty infiltration, are prerequisites for reentry.
  • Anisotropy and heterogeneous repolarization further predispose to ventricular tachyarrhythmias.

Purpose:

  • To investigate the relationship between electrophysiological changes and sustained ventricular tachycardia.
  • To differentiate electrogram characteristics in post-infarct patients with and without VT.
  • To correlate abnormal electrogram findings with the extent of delayed conduction.

Summary:

  • Delayed and inhomogeneous conduction in altered myocardial tissue manifests as abnormal electrograms.

Related Experiment Videos

  • In post-infarct patients with VT, markedly delayed activation over the infarct area was observed.
  • Three electrogram types (late potential, fragmentation, double potentials) signify varying degrees of conduction delay, with fragmentation and double potentials frequently seen in VT patients.

    • Impact:

    • Abnormal electrograms, particularly fragmented and double potentials, are indicative of reentry circuits in VT.
    • The size of areas with abnormal electrograms is significantly larger in patients experiencing VT.
    • These findings enhance the understanding of VT mechanisms and may inform diagnostic strategies.