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Total nephrectomy following Corynebacterium coyleae urinary tract infection
Claudia M Barberis1, Eduardo Montalvo1, Soledad Imas2
1Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica, Departamento de Bioquímica Clínica, Cátedra de Microbiología Clínica, Hospital de Clínicas José de San Martín, Ciudad Autónoma de Buenos Aires, Argentina.
JMM Case Reports
|November 15, 2018
Summary
Corynebacterium coyleae, a rare bacterium, was identified as the cause of a complicated urinary tract infection in a patient with chronic kidney failure. This case highlights C. coyleae as an emerging pathogen in nosocomial infections.
Area of Science:
- Microbiology
- Infectious Diseases
- Urology
Background:
- Corynebacterium coyleae is a Gram-positive bacterium with limited documented clinical relevance.
- Information regarding C. coyleae's role in complicated urinary tract infections (cUTIs) is scarce.
- This study investigates a novel case of cUTI caused by C. coyleae.
Observation:
- A 36-year-old female patient with polycystic kidney disease and chronic kidney failure presented with symptoms of a complicated urinary tract infection.
- Urine and kidney tissue cultures revealed significant growth of Gram-positive coryneform rods.
- The causative agent was identified as Corynebacterium coyleae using MALDI-TOF, biochemical tests, and rpoB gene sequencing.
Findings:
- Corynebacterium coyleae was confirmed as the pathogen responsible for the complicated urinary tract infection.
- The identification was corroborated by multiple microbiological and molecular methods.
- This case represents the first documented instance of C. coyleae causing a complicated urinary tract infection.
Implications:
- Corynebacterium coyleae should be recognized as a potential emerging pathogen in healthcare-associated infections.
- Clinicians should consider C. coyleae in the differential diagnosis of complicated urinary tract infections, especially in immunocompromised patients.
- Further research is warranted to understand the pathogenicity and treatment strategies for C. coyleae infections.
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