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Hepatic Encephalopathy in Patients in Lviv (Ukraine)
1Division of Hepato-gastroenterology of Internal Medicine Department at Lviv Regional Clinical Hospital, Danylo Halytsky Lviv National Medical University, Lviv Ukraine.
Journal of Translational Internal Medicine
|November 15, 2018
Summary
Hepatic encephalopathy (HE) disproportionately affects females and older adults, with alcohol and hepatitis C as primary causes. Neurological assessments indicate poor prognosis in these patients.
Area of Science:
- Hepatology
- Neurology
- Gastroenterology
Background:
- Hepatic encephalopathy (HE) research is hindered by its unclear definition.
- HE is a disabling complication of liver failure with significant impact.
Purpose of the Study:
- To provide an overview of HE etiology and its impact.
- To examine HE's role in neuromuscular function, infections, and anemia.
Main Methods:
- Descriptive study of 36 patients with HE.
- Close monitoring of various clinical and laboratory parameters.
Main Results:
- Alcohol (67%) and Hepatitis C Virus (HCV; 17%) were leading causes of HE.
- Elevated De Ritis levels (69%) and total bilirubin (92%) were common.
- Halstead-Reitan (H-R) scores indicated neuropsychological deficits, predominantly in females.
Conclusions:
- HE shows a higher prevalence in females and patients over 65, who have a poorer survival rate.
- Alcohol and HCV are key etiological factors.
- Child-Pugh grades B and C were prevalent, indicating poor prognosis.
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