The Cognitive Ageing, Nutrition and Neurogenesis (CANN) trial: Design and progress
Michael A Irvine1, Andrew Scholey2, Rebecca King2
1Department of Nutrition and Preventive Medicine, Norwich Medical School, BCRE, University of East Anglia, Norwich, UK.
Alzheimer'S & Dementia (New York, N. Y.)
|November 15, 2018
Summary
This study investigated if omega-3 fatty acids and cocoa flavan-3-ols can slow cognitive decline in older adults. Results are pending but aim to find dietary interventions for cognitive health.
Area of Science:
- Neuroscience
- Nutritional Science
- Gerontology
Background:
- Cognitive decline is a significant concern in aging populations.
- Dietary interventions are being explored to mitigate age-related cognitive impairment.
- The Cognitive Ageing, Nutrition and Neurogenesis trial investigates novel nutritional strategies.
Purpose of the Study:
- To evaluate the efficacy of combined long-chain n-3 polyunsaturated fatty acids (n-3) and cocoa flavan-3-ols (FLAV) in preventing cognitive decline.
- To assess the impact of this intervention on hippocampus-sensitive cognitive functions.
- To explore secondary outcomes including neuroimaging, vascular function, and biomarkers.
Main Methods:
- A double-blinded, placebo-controlled trial with 259 participants with mild cognitive impairment or subjective memory impairment.
- Randomization to either a control group or an intervention group receiving n-3 (1.5 g DHA+EPA) and FLAV (500 mg) daily for 12 months.
- Cognitive assessments at baseline, 3 months, and 12 months, with primary endpoint on hippocampus-sensitive cognitive function.
Main Results:
- Screening commenced in 2015, with baseline data collected by March 2017.
- The intervention period concluded in March 2018.
- Detailed results on cognitive function, neuroimaging, and biomarkers are anticipated.
Conclusions:
- The study aims to identify a diet-based intervention to prevent or delay cognitive impairment in at-risk individuals.
- Findings could contribute to reducing the population burden of dementia.
- This research explores the potential of n-3 fatty acids and cocoa flavan-3-ols for cognitive health maintenance.
Keywords:
Cocoa flavan-3-olsCognitionDementiaDocosahexaenoic acidEicosapentaenoic acidHippocampusMagnetic resonance imagingMild cognitive impairmentSubjective memory impairmentMore Related Videos
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