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Epidemiological Study of Carbapenem-resistant Klebsiella Pneumoniae

Di Lin1, Jian Chen1, Yan Yang1

  • 1Department of Clinical Laboratory Science, The 117th Hospital of PLA, Hangzhou 310013, China.

Open Medicine (Warsaw, Poland)
|November 15, 2018
PubMed
Abstract

Insights

Carbapenem-resistant Klebsiella pneumoniae (CRKP) exhibits high resistance rates and complex molecular characteristics. Understanding these factors is crucial for effective clinical control and prevention strategies.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Molecular Epidemiology

Background:

  • Carbapenem-resistant Klebsiella pneumoniae (CRKP) poses a significant global health threat.
  • Understanding the molecular epidemiology and resistance mechanisms of CRKP is essential for effective treatment and control.

Purpose of the Study:

  • To investigate the resistance patterns and molecular epidemiological features of CRKP strains.
  • To identify the prevalence of key resistance genes and sequence types (STs) in clinical CRKP isolates.

Main Methods:

  • Collection and analysis of 38 CRKP strains from clinical specimens.
  • Antimicrobial resistance profiling.
  • Detection of carbapenemase genes (blaKPC-2, blaIMP-4) and other beta-lactamase genes (blaSHV, blaTEM, blaCT-M, blaDHA-1).
  • Analysis of outer membrane protein (ompK35, ompK36) expression and sequence typing (STs).

Main Results:

  • High resistance rates (>70%) observed, with ampicillin resistance at 100%.
  • Prevalence of blaKPC-2 (89.5%) and blaSHV (94.7%) genes was high.
  • Loss of ompK35 and ompK36 porins was noted in 39.5% of strains.
  • ST11 was the predominant sequence type (86.8%), indicating clonal spread.

Conclusions:

  • CRKP demonstrates severe resistance, with increasingly complex resistance mechanisms.
  • Diverse ST types and resistance genes contribute to CRKP's adaptability and spread.
  • Urgent clinical interventions and control measures are necessary to combat CRKP infections.
Keywords:
Klebsiella pneumoniaecarbapenemresistance

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