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Improved Efficacy of Antibody Cancer Immunotherapeutics through Local and Sustained Delivery

Vincent Huynh1, Alexander H Jesmer1, Muhammad M Shoaib1

  • 1Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario, L8S 4M1, Canada.

Chembiochem : a European Journal of Chemical Biology
|November 15, 2018
PubMed

Antibodies are a growing class of cancer immunotherapeutics that facilitate immune-cell-mediated killing of tumors. However, the efficacy and safety of immunotherapeutics are limited by transport barriers and poor tumor uptake, which lead to high systemic concentrations and potentially fatal side effects. To increase tumor antibody immunotherapeutic concentrations while decreasing systemic concentrations, local delivery vehicles for sustained antibody release are being developed. The focus of this review is to define the material properties required for implantable controlled antibody delivery and highlight the controlled-release strategies that are applicable to antibody immunotherapeutics.

Keywords:
antibodiesantitumor agentscontrolled releasedrug deliveryhydrogelsimmunotherapy

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