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Using the Patient-Reported Outcomes Measurement Information System (PROMIS) to measure symptom burden reported by

Jin-Shei Lai1,2, Mary Jo Kupst3, Jennifer L Beaumont1,4

  • 1Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Pediatric Blood & Cancer
|November 15, 2018
PubMed

Insights

Children with brain tumors experience significant symptom burden. Patient-Reported Outcomes Measurement Information System (PROMIS) tools effectively assess these symptoms and associated factors in pediatric patients.

Area of Science:

  • Pediatric Oncology
  • Clinical Psychology
  • Health Outcomes Research

Background:

  • Children diagnosed with brain tumors face a substantial symptom burden throughout their illness.
  • Understanding this symptom burden and its associated factors is crucial for improving patient care.

Purpose of the Study:

  • To evaluate the symptom burden experienced by children with brain tumors.
  • To identify factors associated with these symptoms in pediatric brain tumor patients.

Main Methods:

  • Analyzed data from 199 children (aged 7-22) with brain tumors.
  • Assessed symptom burden using Patient-Reported Outcomes Measurement Information System (PROMIS) computerized adaptive testing (CAT) for anxiety, depression, fatigue, mobility, upper extremity function, peer relationships, and cognition.
  • Utilized Symptom Distress Scales (SDS) completed by patients and parents; employed statistical tests (ANOVA) to analyze relationships.

Main Results:

  • PROMIS measures strongly correlated with patient and parent-reported Symptom Distress Scales.
  • Fatigue, mobility, and upper extremity function were linked to functional status, treatment modalities, and time since treatment.
  • Cognition and fatigue associated with educational support needs; mobility, upper extremity function, and anxiety linked to radiation and chemotherapy timing.

Conclusions:

  • Established significant associations between PROMIS measures and clinical/demographic characteristics.
  • Demonstrated that brief PROMIS CATs are effective for systematic assessment of symptom burden in pediatric brain tumor patients.
Abstract

Keywords:
CATPROMISbrain tumorchildrenpatient-centered outcomes

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