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Updated: Feb 2, 2026

Clinical Testing and Spinal Cord Removal in a Mouse Model for Amyotrophic Lateral Sclerosis ALS
Published on: March 17, 2012
DNA hydroxymethylation changes in response to spinal cord damage in a multiple sclerosis mouse model
Yan Tang1,2,3, Man Luo1, Kailing Pan3
1Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou City, PR China.
Aim:
Roles of DNA 5-hydroxymethylcytosine (5hmC) in myelin repair were investigated in an experimental autoimmune encephalomyelitis (EAE) mouse model via its regulation on BDNF.
Methods:
DNA 5hmC level and its limiting enzymes were detected in EAE mice.
Results:
Global 5hmC modification, Tet1 and Tet2 significantly decreased in the spinal cord tissues of EAE mice. BDNF protein and mRNA decreased and were highly associated with BDNF 5hmC. Vitamin C, a Tet co-factor, increased global DNA 5hmC and reduced the neurological deficits at least by increasing BDNF 5hmC modification and protein levels.
Conclusion:
Tet protein-mediated 5hmC modifications represent a critical target involved in EAE-induced myelin damage. Targeting epigenetic modification may be a therapeutic strategy for multiple sclerosis.
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