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The quantitative profiling of blood mSEPT9 determines the detection performance on colorectal tumors
Lele Song1,2, Jiayu Wang1,3, Huaiqing Wang1,3
1Department of Radiotherapy, the Chinese PLA 309th Hospital, Beijing, PR China.
Aim:
To investigate the quantitative relationship between the positive detection rate (PDR) in colorectal tumor detection and the mSEPT9 level.
Materials & Methods:
The level of blood mSEPT9 in various colorectal diseases was quantified by the Epi proColon 2.0 assay. ΔΔCt values were calculated representing the mSEPT9 level. A total of 1347 subjects were recruited in this quantitative study.
Results:
PDR or sensitivity was positively correlated with the progression of colorectal tumors and the mSEPT9 level in an exponential relationship. The mSEPT9 level of CRC exhibited a distinct pattern of distribution. Strong correlation was found between mSEPT9 level and PDR or sensitivity in various tumor differentiation, pathological types or metastasis.
Conclusion:
The quantitative profiling of blood mSEPT9 determines the detection performance on colorectal tumors.
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