Diagnosis of Carpal Tunnel Syndrome: Value of Ultrasound Compared to Nerve Conduction Studies Abstract. Carpal tunnel syndrome is the most common compression syndrome of the peripheral nerves. The patient's history with nocturnal brachialgia, daytime brachialgia, nocturnal paraesthesia and daytime paraesthesia (part of the 6-item CTS symptom scale) and a specific clinical exam take part while making a diagnosis. Additional diagnostics include electrophysiological testings. A high-resolution ultrasound examination for the evaluation of the morphology of the median nerve has gained importance in diagnosis of a carpal tunnel syndrome, whilst an electrophysiological exam allows a functional evaluation. Cardinal finding in ultrasound is an absolute or relative enlargement of the cross-section of the nerve at the edge proximal to the flexor retinaculum. Despite multiple studies that demonstrated ultrasound as a fist-line diagnostic tool, there is no consensus on optimal sonographic criteria for the definition of a compressed median nerve. Our aim was to demonstrate the use of ultrasound and electrophysiological exams for diagnostics of carpal tunnel syndrome in our own patient population and compared to the literature.