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Updated: Feb 2, 2026

Generating a Fractal Microstructure of Laminin-111 to Signal to Cells
Published on: September 28, 2020
The Effect of Laminin-111 Hydrogels on Muscle Regeneration in a Murine Model of Injury
Madison Marcinczyk1, Andrew Dunn1, Gabriel Haas1
1Department of Biomedical Engineering, Parks College of Engineering, Aviation, and Technology, St. Louis, Missouri.
Impact Statement:
Extremity injuries make up the most common survivable injuries in vehicular accidents and modern military conflicts. A majority of these injuries involve volumetric muscle loss (VML). The potential for donor site morbidity may limit the clinical use of autologous muscle grafts for VML injuries. Treatments that can improve the regeneration of functional muscle tissue are critically needed to improve limb salvage and reduce the rate of delayed amputations. The development of a laminin-111-enriched fibrin hydrogel will offer a potentially transformative and "off-the-shelf" clinically relevant therapy for functional skeletal muscle regeneration.
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