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Denaturing Urea Polyacrylamide Gel Electrophoresis Urea PAGE
Published on: October 29, 2009
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Can urea breath test (UBT) replace rapid urea test (RUT)?
Łukasz Nawacki1, Agata Czyż2, Piotr Bryk3
1Regional Polyclinical Hospital in Kielce Department of General, Oncological and Endocrine Surgery.
Polski Przeglad Chirurgiczny
|November 15, 2018
Summary
The Carbon-13 urea breath test (UBT) is a sensitive and specific method for detecting Helicobacter pylori infection. Early detection and eradication of H. pylori can prevent gastric cancer development.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Oncology
Background:
- Helicobacter pylori (Hp) is a Group 1 carcinogen linked to gastric cancer.
- Early detection and eradication of Hp are crucial for disease prevention.
Purpose of the Study:
- To analyze the clinical and practical value of the Carbon-13 urea breath test (UBT).
- To evaluate UBT in patients with upper abdominal pain and dyspeptic symptoms.
Main Methods:
- Fifty patients with dyspeptic symptoms underwent UBT.
- Endoscopy with mucosal biopsy and rapid urease test (RUT) were performed for comparison.
Main Results:
- UBT showed 28% positive results confirmed by RUT.
- Discrepancies were observed: 8% positive UBT with negative RUT, and 4% negative UBT with positive RUT.
Conclusions:
- UBT is a highly sensitive and specific diagnostic method for H. pylori infection.
- UBT can guide the initiation of eradication therapy, especially when gastroscopy is unavailable.
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