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Autism Spectrum Disorders and Celiac Disease: Is there an Association?

Monica Juneja1, Abhinaya Venkatakrishnan1, Seema Kapoor1

  • 1Child Development Center, Department of Pediatrics, Maulana Azad Medical College and associated Lok Nayak Hospital, New Delhi, India.

Indian Pediatrics
|November 15, 2018
PubMed

Insights

This study found no link between Autism Spectrum Disorders (ASD) and Celiac disease in 150 children. Screening for Celiac disease using specific antibodies showed negative results in all participants with ASD.

Area of Science:

  • Pediatric Gastroenterology
  • Neurodevelopmental Disorders
  • Immunology

Background:

  • Autism Spectrum Disorders (ASD) are complex neurodevelopmental conditions.
  • Celiac disease is an autoimmune disorder triggered by gluten.
  • Previous research has explored potential links between ASD and gastrointestinal issues, including Celiac disease.

Discussion:

  • This study investigated the prevalence of Celiac disease in children diagnosed with Autism Spectrum Disorders.
  • Utilizing anti-tissue transglutaminase IgA antibody screening, researchers assessed 150 children aged 2-12 years with ASD and normal serum total IgA.
  • All participants screened negative for Celiac disease.

Key Insights:

  • No positive association was found between Autism Spectrum Disorders and Celiac disease in the studied pediatric cohort.
  • Normal serum total IgA levels were observed in all participating children with ASD.
  • The findings suggest that Celiac disease may not be a common comorbidity in children with ASD.

Outlook:

  • Further research with larger cohorts and diverse populations is warranted to confirm these findings.
  • Investigating other gastrointestinal conditions in children with ASD may provide additional insights.
  • Understanding the interplay between neurodevelopment and immune responses remains a critical area for future study.

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