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Updated: Feb 2, 2026

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
Published on: December 27, 2013
Electrospun PLGA membrane incorporated with andrographolide-loaded mesoporous silica nanoparticles for sustained
Yuhang Jia1, Hongbo Zhang1, Shengbing Yang2
1School of Mechanical & Power Engineering, Complex and Intelligent Systems Research Centre, East China University of Science & Technology, Shanghai 200237, China.
Aim:
To assess the wound-healing ability of poly(lactic-co-glycolic acid) (PLGA) nanofibrous wound dressing incorporated with andrographolide (Andro)-loaded mesoporous silica nanoparticles (MSNs).
Materials & Methods:
PLGA/Andro-MSNs nanofibrous membrane wound dressings were produced by electrospinning. The effects of MSNs on the hydrophilicity, degradation and mechanical strength of membranes were evaluated. The cumulative release of Andro in vitro was obtained. Cell culture and in vivo tests on infectious models were carried out.
Results:
The PLGA/Andro-MSNs membrane showed a sustained release of Andro. The incorporation of MSNs into PLGA improved the hydrophilicity of the nanofibrous membranes. Cell culture and in vivo tests showed that PLGA/Andro-MSNs membrane can promote epidermal cell adhesion and reduce inflammation process.
Conclusion:
PLGA/Andro-MSNs nanofibrous membrane exhibited an efficient wound-healing ability.
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