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Acetylcholinesterase activity and bone biochemical markers in premature and full-term neonates

Charalampos Dokos1, Christos Tsakalidis2, Kyriakoula Manaridou2,3

  • 12nd Neonatal Clinic, Papageorgiou University Hospital, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece, Phone: +4917661465941.

Journal of Pediatric Endocrinology & Metabolism : JPEM
|November 15, 2018
PubMed

Insights

Acetylcholinesterase (AChE) activity increases with gestational age in premature infants. This study found correlations between AChE, bone biomarkers, and gestational age, suggesting AChE

Area of Science:

  • Neonatal Medicine
  • Biochemistry
  • Pediatric Endocrinology

Background:

  • Premature infants often exhibit low bone mineral density, necessitating effective screening for metabolic bone disease.
  • Acetylcholinesterase (AChE) is increasingly recognized for its role in bone remodeling processes.
  • Current screening protocols for metabolic bone disease in neonates lack consensus.

Purpose of the Study:

  • To investigate the potential correlation between bone biochemical markers and acetylcholinesterase (AChE) activity in premature infants.
  • To explore the relationship between gestational age and AChE activity and bone health indicators.

Main Methods:

  • Serum bone biochemical markers (alkaline phosphatase, calcium, phosphorus, magnesium, parathyroid hormone) and AChE activity were measured in 50 neonates (26 preterm, 24 full-term).
  • Clinical and anthropometric data, including gestational age and body weight, were recorded.
  • Statistical analysis was performed to identify correlations between variables.

Main Results:

  • Premature neonates showed lower serum calcium (Ca), phosphorus (P), and AChE activity compared to full-term infants.
  • Higher levels of alkaline phosphatase (ALP) and parathyroid hormone (PTH) were observed in the preterm group.
  • Significant positive correlations were found between gestational age, body weight, Ca, and AChE.
  • Gestational age exhibited significant negative correlations with ALP and PTH.

Conclusions:

  • Acetylcholinesterase (AChE) activity demonstrates a clear increase with advancing gestational age in neonates.
  • Significant relationships were identified between AChE activity, phosphorus (P), and parathyroid hormone (PTH) levels.
  • These findings suggest AChE may serve as a potential biomarker related to bone metabolism in premature infants.

Keywords:
acetylcholinesterasebone biomarkersbone metabolismmetabolic bone disease of prematuritypremature infants

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