Bone Quality and Quantity Alterations After Socket Augmentation with rhPDGF-BB or BMPs: A Systematic Review

Area of Science:

• Dental surgery
• Regenerative medicine
• Biomaterials

Background:

• Socket preservation is crucial for maintaining alveolar ridge dimensions after tooth extraction.
• Growth factors like BMPs and rhPDGF-BB are investigated for their potential to enhance bone regeneration.
• Comparing their efficacy against natural healing is essential for clinical application.

Purpose of the Study:

• To systematically review the effects of BMPs and rhPDGF-BB on volumetric and histomorphometric changes in socket augmentation.
• To compare these effects with natural healing outcomes in extraction sockets.

Main Methods:

• A comprehensive electronic and hand search of human clinical trials was conducted.
• Studies reporting quantitative and qualitative outcomes of soft and hard tissues were included.
• Eight studies (6 RCTs, 2 case series) met the inclusion criteria.

Main Results:

• BMPs significantly improved linear bone width compared to natural healing (WMD = 1.66 mm, P = .02).
• rhPDGF-BB did not show a significant difference in vital bone percentage compared to grafting materials alone (WMD = 2.16%, P = .53).

Conclusions:

• BMPs demonstrate efficacy in improving ridge width during socket augmentation.
• Further investigation is required to establish the clinical benefits of rhPDGF-BB in socket augmentation procedures.