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Related Experiment Videos

Benzodiazepines in depressive disorders.

A F Schatzberg, J O Cole

    Archives of General Psychiatry
    |November 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Benzodiazepines are not effective antidepressants for most depressive illnesses. While they reduce anxiety and may slightly improve mood, they do not treat core depression symptoms effectively.

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    Area of Science:

    • Psychiatry
    • Pharmacology

    Background:

    • Benzodiazepines have been proposed as antidepressants due to their effects on anxious depression.
    • Their efficacy in treating various depressive disorders requires thorough investigation.

    Purpose of the Study:

    • To review the existing literature on the use of benzodiazepines in depressive disorders.
    • To evaluate the effectiveness of benzodiazepines compared to standard antidepressants.

    Main Methods:

    • Literature review of studies comparing benzodiazepines with standard antidepressants.
    • Analysis of benzodiazepine effects on anxiety, mood, and core depressive symptoms.

    Main Results:

    • Comparative studies show benzodiazepines are less effective than standard antidepressants for several depression types.

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  • Benzodiazepines possess anxiolytic properties and can elevate mood but have limited impact on endogenous depression core symptoms.

    • Conclusions:

    • Benzodiazepines are primarily anxiolytic agents, not effective antidepressants.
    • Their use should be considered for anxiety symptoms rather than as a primary treatment for depression.