Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pedigree Analysis01:35

Pedigree Analysis

89.4K
Overview
89.4K
Biodiversity and Human Values01:24

Biodiversity and Human Values

17.1K
Human civilization relies on biodiversity in many ways. Sudden changes in species biodiversity result in environmental changes that can modify weather patterns and therefore human civilizations.
17.1K
Qualitative Analysis03:46

Qualitative Analysis

24.3K
For solutions containing mixtures of different cations, the identity of each cation can be determined by qualitative analysis. This technique involves a series of selective precipitations with different chemical reagents, each reaction producing a characteristic precipitate for a specific group of cations. Metal ions within a group are further separated by varying the pH, heating the mixture to redissolve a precipitate, or adding other reagents to form complex ions.
For instance, group IV...
24.3K
Dimensional Analysis03:40

Dimensional Analysis

64.5K
Dimensional analysis, also known as the factor label method, is a versatile approach for mathematical operations. The main principle behind this approach is: the units of quantities must be subjected to the same mathematical operations as their associated numbers. This method can be applied to computations ranging from simple unit conversions to more complex and multi-step calculations involving several different quantities and their units.
Conversion Factors and Dimensional Analysis
The unit...
64.5K
Dimensional Analysis01:27

Dimensional Analysis

672
Dimensional analysis is a valuable technique in fluid mechanics for simplifying complex problems by reducing them into dimensionless groups. These groups capture the essential relationships between the variables involved, allowing researchers and engineers to analyze fluid flow without dealing with each variable individually. This approach reduces the number of independent variables, allowing for easier analysis and better understanding of physical phenomena.
In fluid mechanics, dimensional...
672
Human Genetics01:28

Human Genetics

1.6K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

EpiATLAS - a reference for human epigenomic research.

bioRxiv : the preprint server for biology·2026
Same author

Hematopoietic stem cells in human fetal liver selectively express CD49f.

Experimental hematology·2025
Same author

Coordinated regulation of self-renewal and cell cycle during human lympho-myeloid lineage restriction.

Blood·2025
Same author

Comparative small molecule screening of primary human acute leukemias, engineered human leukemia and leukemia cell lines.

Leukemia·2024
Same author

Dependence of human cell survival and proliferation on the CASP3 prodomain.

Cell death discovery·2024
Same author

Identification of multivariable microRNA and clinical biomarker panels to predict imatinib response in chronic myeloid leukemia at diagnosis.

Leukemia·2023

Related Experiment Video

Updated: Feb 2, 2026

Flow Cytometric Analysis of Natural Killer Cell Lytic Activity in Human Whole Blood
08:14

Flow Cytometric Analysis of Natural Killer Cell Lytic Activity in Human Whole Blood

Published on: March 17, 2017

12.8K

A Prospective Analysis of Human Leukemogenesis.

Connie J Eaves1

  • 1Terry Fox Laboratory, British Columbia Cancer Agency and Department of Medical Genetics, University of British Columbia, British Columbia Cancer Research Centre, 675 West 10(th) Avenue, Vancouver, BC V5Z 1L3, Canada.

Stem Cell Reports
|November 15, 2018
PubMed
Summary

New approaches are needed for fatal blood cancers. Researchers are recreating human leukemia using genetic methods to understand early leukemic events and develop targeted therapies.

More Related Videos

Dissection of Human Retina and RPE-Choroid for Proteomic Analysis
06:54

Dissection of Human Retina and RPE-Choroid for Proteomic Analysis

Published on: November 12, 2017

11.8K
Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
04:09

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Published on: March 3, 2023

3.8K

Related Experiment Videos

Last Updated: Feb 2, 2026

Flow Cytometric Analysis of Natural Killer Cell Lytic Activity in Human Whole Blood
08:14

Flow Cytometric Analysis of Natural Killer Cell Lytic Activity in Human Whole Blood

Published on: March 17, 2017

12.8K
Dissection of Human Retina and RPE-Choroid for Proteomic Analysis
06:54

Dissection of Human Retina and RPE-Choroid for Proteomic Analysis

Published on: November 12, 2017

11.8K
Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
04:09

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Published on: March 3, 2023

3.8K

Area of Science:

  • Hematology
  • Oncology
  • Molecular Biology

Background:

  • Significant challenges persist in treating fatal hematologic malignancies.
  • Targeting early events in leukemogenesis is crucial for developing effective therapies.
  • Understanding clonal dynamics and mutation acquisition is key to leukemia research.

Purpose of the Study:

  • To explore novel strategies for treating blood cancers.
  • To recreate human leukemia de novo using defined genetic methods.
  • To gain insights into primitive hematopoietic cell regulation for therapeutic advancements.

Main Methods:

  • Retrospective analysis of mutation representation in leukemic cells.
  • Prospective recreation of human leukemia using genetic engineering.
  • Utilizing primary chronic myeloid leukemia cells and normal cord blood cells.

Main Results:

  • Demonstrated feasibility of recreating human leukemia in vitro.
  • Provided insights into the properties and regulation of primitive hematopoietic cells.
  • Established a foundation for developing new therapeutic strategies.

Conclusions:

  • Recreating human leukemia offers a powerful prospective approach to study leukemogenesis.
  • Understanding normal hematopoietic cell regulation is vital for advancing leukemia treatment.
  • This research paves the way for novel targeted therapies against blood cancers.