Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mismatch Repair01:36

Mismatch Repair

43.7K
Overview
43.7K
Mismatch Repair01:20

Mismatch Repair

6.6K
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
6.6K
Overview of DNA Repair02:25

Overview of DNA Repair

33.7K
In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...
33.7K
Base Excision Repair01:54

Base Excision Repair

26.3K
One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...
26.3K
Nucleotide Excision Repair01:08

Nucleotide Excision Repair

40.9K
Overview
40.9K
Long-patch Base Excision Repair01:02

Long-patch Base Excision Repair

8.0K
Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
8.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ulnar Neuroma-in-Continuity Following Distal Radius Fracture: A Rare Complication Requiring Reconstruction with Nerve Allograft and Dynamic Tendon Transfer.

Journal of hand surgery global online·2026
Same author

A Simple, Single-Staged Pedicled Rotational Flap With Lateral Band Tendon Graft for the Reconstruction of Composite Dorsal Finger Defects.

Cureus·2025
Same author

Factors Affecting Appearance after Thumb Polydactyly Reconstruction - A Caregiver's Perspective in an Asian Population.

The journal of hand surgery Asian-Pacific volume·2024
Same author

Current trends in digital replantation-a narrative review.

Annals of translational medicine·2024
Same author

Bilobed Flap Coverage for the Reconstruction of Dorsal Soft Tissue Defect Over the Proximal Phalanx: A Case Report.

Cureus·2024
Same author

The role of reconstructive microsurgeons in liver transplantation-a narrative review.

Annals of translational medicine·2024

Related Experiment Video

Updated: Feb 2, 2026

Murine Flexor Tendon Injury and Repair Surgery
07:32

Murine Flexor Tendon Injury and Repair Surgery

Published on: September 19, 2016

13.7K

Flexor Tendon Injuries and Repairs: A Single Centre Experience.

Min Kai Chang1, Shian Chao Tay1,2

  • 1* Duke-NUS Medical School, Singapore.

The Journal of Hand Surgery Asian-Pacific Volume
|November 16, 2018
PubMed
Summary

This study analyzed 214 patients with flexor tendon injuries, finding males aged 20-29 in manual labor most at risk, often from glass-related work injuries. Findings aid in managing and preventing these common hand injuries.

Keywords:
EpidemiologyFlexor tendon injuryFlexor tendon repairHandTrauma

More Related Videos

Using Q Suture to Enhance Resistance to Gap Formation and Tensile Strength of Repaired Flexor Tendons
10:32

Using Q Suture to Enhance Resistance to Gap Formation and Tensile Strength of Repaired Flexor Tendons

Published on: June 3, 2020

6.3K
Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms
08:32

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms

Published on: March 22, 2024

1.8K

Related Experiment Videos

Last Updated: Feb 2, 2026

Murine Flexor Tendon Injury and Repair Surgery
07:32

Murine Flexor Tendon Injury and Repair Surgery

Published on: September 19, 2016

13.7K
Using Q Suture to Enhance Resistance to Gap Formation and Tensile Strength of Repaired Flexor Tendons
10:32

Using Q Suture to Enhance Resistance to Gap Formation and Tensile Strength of Repaired Flexor Tendons

Published on: June 3, 2020

6.3K
Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms
08:32

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms

Published on: March 22, 2024

1.8K

Area of Science:

  • Orthopedic Surgery
  • Hand Surgery
  • Trauma Surgery

Background:

  • Flexor tendon injuries present significant morbidity and socio-economic challenges.
  • Limited data exists on patient demographics, injury patterns, and surgical specifics for these injuries.
  • This study addresses the need for comprehensive data on flexor tendon injuries and repairs.

Purpose of the Study:

  • To describe the experience with digital flexor tendon injuries and their surgical repairs.
  • To identify demographic and injury characteristics associated with flexor tendon injuries.
  • To detail surgical interventions for flexor tendon injuries.

Main Methods:

  • Retrospective study of digital flexor tendon injuries repaired between January 2011 and December 2014.
  • Data collection included patient demographics, injury characteristics, and surgical details.
  • Analysis of 214 patients, 308 digits, and 446 flexor tendon repairs.

Main Results:

  • Males, non-residents, and individuals aged 20-29 were most susceptible.
  • Vulnerable occupations included cleaners and laborers, with glass-related work injuries being common.
  • Zone 2 lacerations of the non-dominant hand, often involving both flexor digitorum profundus and superficialis tendons, were frequent, with concomitant nerve and vessel injuries.
  • Procedures typically lasted 1-2 hours and involved multiple repairs, including microsurgical interventions.

Conclusions:

  • This represents the largest study detailing demographics, injury characteristics, and surgical aspects of flexor tendon injuries.
  • Findings can inform resource allocation and policy development for managing and preventing flexor tendon injuries.
  • The study provides a foundation for future research and clinical guidelines in hand trauma.