Related Experiment Video

Updated: Feb 2, 2026

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
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Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation

Published on: May 20, 2020

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Capivasertib Active against AKT1-Mutated Cancers

    Cancer Discovery
    |November 16, 2018
    PubMed

    Insights

    The experimental drug capivasertib stabilized or shrank tumors in most patients with AKT1-mutant cancers. This AKT inhibitor shows promise for treating specific metastatic tumors.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Clinical Trials

    Background:

    • Metastatic cancers with AKT1 mutations represent a targetable population for therapy.
    • The NCI-MATCH trial investigated targeted therapies in patients with specific genetic alterations.

    Discussion:

    • Capivasertib, a pan-AKT inhibitor, demonstrated anti-tumor activity in patients with AKT1-mutant metastatic disease.
    • Tumor stabilization or shrinkage was observed in a majority of treated patients.

    Key Insights:

    • Targeting AKT signaling with capivasertib is a viable strategy for AKT1-mutant cancers.
    • The U.S.-wide NCI-MATCH trial provides crucial data on the efficacy of this experimental agent.

    Outlook:

    • Further clinical development of capivasertib for AKT1-mutant tumors is warranted.
    • This finding may inform future treatment strategies for patients with similar molecular profiles.

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