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In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded...
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Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease
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Tackling potentially inappropriate prescribing

Anthony J Avery1, Jamie J Coleman2

  • 1Division of Primary Care, School of Medicine, University of Nottingham, Nottingham NG7 2UH, UK.

BMJ (Clinical Research Ed.)
|November 16, 2018
PubMed
Summary

No abstract available in PubMed .

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