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Changes in hepatitis C virus genotype distribution in chronic hepatitis C infection patients

Mehmet Burak Selek1, Orhan Baylan1, Ergenekon Karagöz2

  • 1Department of Medical Microbiology, Sultan Abdülhamid Han Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.

Indian Journal of Medical Microbiology
|November 16, 2018
PubMed

Insights

Hepatitis C virus (HCV) genotype 1b is most common in chronic hepatitis C (CHC) patients. Understanding HCV genotype distribution is crucial for effective antiviral treatment strategies.

Area of Science:

  • Hepatology
  • Virology
  • Infectious Diseases

Background:

  • Accurate identification of hepatitis C virus (HCV) genotypes is essential for guiding antiviral therapy, optimizing drug dosages, and determining treatment duration.
  • The distribution of HCV genotypes can vary geographically and is influenced by demographic and social factors.

Purpose of the Study:

  • To investigate the distribution pattern of HCV genotypes among patients with chronic hepatitis C (CHC) infection.
  • To provide data that can inform clinical decisions regarding HCV treatment and management.

Main Methods:

  • A total of 106 CHC patients with positive anti-HCV and HCV-RNA tests were included in this 16-month study.
  • HCV RNA testing and genotyping were performed using real-time polymerase chain reaction (RT-PCR).
  • Anti-HCV assays utilized a chemiluminescent microparticle immunoassay.

Main Results:

  • HCV genotype 1b was the predominant genotype, found in 67.0% of patients.
  • HCV genotype 3 was detected in 16.0%, genotype 1a in 14.2%, and genotype 2 in 2.8%.
  • Genotypes 4, 5, and 6 were not detected. No significant differences in genotype distribution were observed based on gender or age.

Conclusions:

  • The study highlights the prevalence of specific HCV genotypes, with genotype 1b being most common.
  • The detection rate of genotype 3 was notably high compared to other studies in the country.
  • Social factors like immigration and commercial activities may influence HCV genotype distribution, necessitating regular, multicenter surveillance studies.
Abstract

Keywords:
Chronic hepatitis Cgenotypinghepatitis C virus

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