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Right ventricular monophasic action potential during quinidine induce marked T and U waves abnormalities
Acta Cardiologica
|January 1, 1977
Summary
Quinidine can cause significant T and U wave abnormalities, including giant waves and alternans, even during normal sinus rhythm. These cardiac changes, characterized by prolonged ventricular action potential duration, resolved after discontinuing quinidine.
Area of Science:
- Cardiology
- Clinical Electrophysiology
- Pharmacology
Background:
- Quinidine is an antiarrhythmic medication known to affect cardiac repolarization.
- T and U wave abnormalities can indicate underlying cardiac electrical disturbances.
Observation:
- A case presented with unusually large T and U wave abnormalities and alternans during sinus rhythm.
- These abnormalities were temporally associated with quinidine administration.
Findings:
- Right ventricular monophasic action potential recordings revealed marked prolongation of action potential duration during the observed T and U wave abnormalities.
- The cardiac repolarization abnormalities regressed upon withdrawal of quinidine.
Implications:
- This case highlights a rare but significant adverse effect of quinidine on cardiac repolarization.
- Understanding these quinidine-induced changes is crucial for accurate diagnosis and patient management.
- Further research may elucidate the precise mechanisms of quinidine-induced T and U wave alternans.