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A Novel Perspective Linkage Between Kidney Function and Alzheimer's Disease
Yan Shi1,2, Zhangsuo Liu2, Yong Shen1,3
1Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing, China.
Frontiers in Cellular Neuroscience
|November 16, 2018
Summary
Chronic kidney disease (CKD) is linked to cognitive impairment and Alzheimer's disease (AD). This review explores the kidney-brain connection, focusing on how impaired kidney function may affect brain health.
Area of Science:
- Nephrology
- Neurology
- Neuroscience
Background:
- Chronic kidney disease (CKD) is associated with increased risk of cognitive impairment and Alzheimer's disease (AD).
- Cognitive deficits in CKD patients correlate with disease progression and renal failure.
- Improved cognitive function post-kidney transplantation suggests a direct link between kidney health and brain function.
Purpose of the Study:
- To explore the intricate relationship between chronic kidney disease (CKD) and Alzheimer's disease (AD).
- To propose a novel perspective on the mechanisms connecting kidney dysfunction to brain health.
Main Methods:
- Literature review focusing on clinical studies and physiological mechanisms.
- Analysis of the impact of kidney function on cerebrovascular circulation and brain health.
Main Results:
- Impaired kidney function can lead to systemic ischemia and hypoxia, affecting the brain.
- Accumulation of urinary toxins in CKD may contribute to neurodegeneration and cognitive decline.
Conclusions:
- The kidney plays a crucial role in maintaining brain homeostasis.
- Understanding the kidney-brain axis is vital for developing new therapeutic strategies for cognitive impairment in CKD and AD.
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