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Updated: Feb 2, 2026
Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
Published on: September 22, 2020
Predictive factors for major amputation of lower limb in diabetic foot: about 430 patients
Insights
Identifying predictive factors for lower limb major amputation in diabetic foot patients is crucial. Age 65 or older is the sole independent predictor, increasing amputation risk by 1.9 times.
Area of Science:
- Diabetic foot complications
- Lower limb amputation
- Predictive factor analysis
Background:
- Major lower limb amputation involves leg or thigh removal.
- Diabetic foot lesions are a significant cause of lower limb amputation.
- Identifying predictors for amputation in diabetic patients is essential.
Purpose of the Study:
- To identify predictive factors for major lower limb amputation in diabetic patients admitted for foot lesions.
- To analyze administrative data for amputation risk factors.
Main Methods:
- Retrospective study (June 2008 - December 2011) of diabetic foot patients.
- Inclusion criteria: infected diabetic foot admission to surgery unit.
- Analysis included descriptive, univariate, and multivariate studies.
Main Results:
- 319 men and 111 women enrolled; average age 60.5 ± 12 years.
- 24% of patients underwent major amputation.
- Univariate analysis identified factors like prior inpatient status, readmission, ICU stay, and age ≥ 65.
- Multivariate analysis revealed age ≥ 65 as the only independent predictor (p=0.004).
Conclusions:
- Age is the sole independent predictive factor for major lower limb amputation in diabetic foot patients.
- Patients aged 65 and above have a 1.9 times higher risk of major amputation.
- An age threshold of 65 years demonstrates significant predictive value.
Background:
Major amputation of the lower limb is defined by a leg or thigh amputation. The aim of our work was identifying predictive factors for lower limb major amputation in patients with diabetes admitted on for foot lesions through using an administrative data base.
Methods:
It was a retrospective study ranging from June 1st, 2008 to December 31st, 2011, which included all the patients admitted on for an infected diabetic foot to the surgery unit B of Charles Nicolle hospital in Tunis. The main judgement criterion was the major amputation of the lower limb. We have done a descriptive and a comparative study, with univariate and multivariate analysis.
Results:
We have enrolled 319 men and 111 women. The average age was 60.5 ± 12 years. Ninety five patients (24%) had a major amputation. Former inpatient, patient readmitted within one month post-operatively, stay in intensive care, admission in intensive care within 48hours after admission, age ≥ 65 years, presence of kidney problem, preoperative stay and length of intervention were identified as predictive factors of major amputation in the univariate analysis. Age was the only independent variable predictive for major amputation which appeared from the multivariate analysis (p=0.004). The age cut-off ≥ 65 years has a specificity of 69 % and a sensitivity of 47% [p=0.004, OR=1.971, IC 95% : 1.239-3.132].
Conclusions:
Age was the only independent predictive factor for major amputation of the lower limb in the diabetic foot with a threshold value higher or equal to 65 years. Patients aged more than 65 had 1.9 time more risk to undergo major amputation of the lower limb.
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