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Neonatal Cardiac Scaffolds: Novel Matrices for Regenerative Studies
Published on: November 5, 2016
Particularities of neonatal isthmic aortic coarctation (A Tunisian study)
Insights
Neonatal coarctation of the aorta requires early diagnosis and management. This study highlights its unique characteristics and successful surgical and interventional treatments, including angioplasty for recoarctation.
Area of Science:
- Pediatric Cardiology
- Cardiovascular Surgery
- Neonatal Medicine
Background:
- Coarctation of the aorta (CoA) is a congenital heart defect.
- Neonatal CoA presents unique clinical and echocardiographic features.
- Early diagnosis is crucial for optimal management.
Purpose of the Study:
- To describe the clinical, echocardiographic, and therapeutic characteristics of neonatal coarctation of the aorta.
- To evaluate the outcomes of surgical and interventional treatments for CoA.
Main Methods:
- Retrospective study of 47 neonates with coarctation of the aorta.
- Data collected from 2000 to 2017 at a pediatric cardiology department.
- Analysis of clinical presentation, echocardiographic findings, associated anomalies, and treatment outcomes.
Main Results:
- 36 girls and 11 boys, average age 14 days.
- Common associated anomalies included patent ductus arteriosus (68%) and atrial septal defect (55.5%).
- Surgical repair in 42 patients showed good immediate results, with 12.5% early mortality. Two late deaths and six cases of recoarctation were treated successfully with angioplasty.
Conclusions:
- Neonatal coarctation of the aorta is distinct from adult forms.
- Early antenatal diagnosis is recommended for improved management.
- Multidisciplinary approach involving surgery and interventional cardiology ensures favorable outcomes.
Methods:
This is a retrospective study including 47 patients with isthmic coarctation (CoA) diagnosed in ante et postnatal périod, hospitalized in pediatric cardiology departement of la Rabta Hospital-Tunisia during the period from 2000 to 2017.
Results:
They were 36 girls and 11 boys with an average age of 14 days. The diagnosis of CoA was suspected during the anténatalperiod in eight cases. In postnatal period heart failure was observed in (38.5%), abolition of femoral pulse (74%), a tension asymetry was found in all patients. Antenatal echocardiography suspected indicators of fetal coarctation especially ventriculo-arterial asymmetryechocardiography confirmed the diagnosis of CoA ,The ejection fraction was impaired in 31% of the cases.The abnormalities associated with coarctation were dominated by the patent ductus arteriosus (68%), atrial septal defect (55.5%), aortic hypoplasia, bicuspidia in respectively in 34% and 31% coarctation syndrome in (23.4%). Prostaglandin wasneccessary in (89.3%). forty two patients were operated with good immédiaterésults. the early postoperative mortality was 12.5%. In the long term, we deplored two late deaths, six cases of recoarctation with a follow-up of 14 months treated by percutaneous angioplasty with a result considered good in all cases.
Conclusion:
Coarctation of the aorta in neonates is a special form of aorticcoarctaion that differs from the child and adult forms in clinical, echocardiographic, and therapeutic characteristics . His clinical diagnosis must be early, if possible in antenatal , to asssure optimal management.
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