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Sensitization to fragrances in Spain: A 5-year multicentre study (2011-2015).
Juan F Silvestre1, Pedro Mercader2, Ricardo González-Pérez3
1Department of Dermatology, Hospital General Universitario de Alicante, Alicante, Spain.
Specific fragrance series testing is recommended for all patients with positive fragrance markers. This approach enhances diagnostic accuracy for contact allergies, identifying key allergens like geraniol.
Area of Science:
- Dermatology
- Allergology
- Contact Dermatitis Research
Background:
- Fragrance chemicals are a leading cause of contact allergy in Spain.
- Limited data exist on specific fragrance allergens responsible for positive reactions.
Purpose of the Study:
- To evaluate the diagnostic value of specific fragrance series compared to baseline fragrance markers.
- To correlate patch test results between baseline and specific fragrance series.
Main Methods:
- A 5-year retrospective study involving 23 Spanish centers.
- Analysis of patch test results from 19,588 patients tested with baseline and specific fragrance series.
Main Results:
- 8.1% of patients showed positive reactions to fragrance markers.
- Geraniol was identified as the most frequent allergen.
- A significant number of patients had positive reactions to fragrances not included in standard fragrance mixes (FM I and FM II).
Conclusions:
- Patch testing with specific fragrance series is recommended for all patients with positive fragrance markers.
- Increasing fragrance concentrations may improve correlation between baseline and specific series results.
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