Related Experiment Video
Updated: Feb 2, 2026

Assessment and Communication for People with Disorders of Consciousness
Published on: August 1, 2017
Selegiline in Patients With Disorder of Consciousness: An Open Pilot Study
Orsola Masotta1, Luigi Trojano2, Vincenzo Loreto1
1Maugeri Scientific and Clinical Institutes, IRCCS, Disorders of Consciousness Laboratory, Institute of Telese Terme, Telese Terme, Benevento, Italy.
Abstract:
This open study investigated the clinical effects of 10-week selegiline administration in six patients in vegetative state and in four patients in a minimally conscious state, at least 6 months after onset. Clinical outcome was assessed by Coma Recovery Scale-Revised once a week during selegiline administration and 1 month later. Three patients stopped treatment because of possible side effects. After treatment and at 1 month of follow-up, four patients showed improvements in clinical diagnosis, and three patients showed an increase in arousal level only. Selegiline might represent a relatively safe option to enhance arousal and promote recovery in brain-injured patients with disorders of consciousness.
Related Concept Videos
Pilot and Numeric Relaying
Understanding Consciousness
Sleep, a crucial state, is characterized by reduced...
Intrinsically Disordered Proteins
Bioavailability Study Design: Healthy Subjects Versus Patients
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Disorders of Erythrocytes
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...

