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Fosfomycin: mechanisms and the increasing prevalence of resistance

Mina Aghamali1, Mansour Sedighi2, Abed Zahedi Bialvaei2

  • 11​Department of Microbiology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Journal of Medical Microbiology
|November 16, 2018
PubMed

Insights

Global microbial resistance is rising, posing challenges for antibiotics like fosfomycin. This review examines the mechanisms and prevalence of fosfomycin resistance, highlighting critical data gaps.

Area of Science:

  • Microbiology
  • Pharmacology
  • Infectious Diseases

Background:

  • Rising global rates of microbial resistance and novel resistance mechanisms present significant challenges.
  • Fosfomycin is a broad-spectrum bactericidal antibiotic crucial for treating Gram-negative and certain Gram-positive bacterial infections.
  • Despite extensive research over 40 years, comprehensive data on fosfomycin resistance prevalence remains limited.

Purpose of the Study:

  • To review and synthesize available data on the mechanisms of fosfomycin resistance.
  • To assess the current understanding of the increasing prevalence of fosfomycin resistance.
  • To identify knowledge gaps regarding fosfomycin resistance patterns.

Main Methods:

  • Literature review of studies on fosfomycin resistance.
  • Analysis of data on antimicrobial resistance mechanisms.
  • Synthesis of information on fosfomycin's efficacy and resistance trends.

Main Results:

  • Fosfomycin effectively targets bacterial cell wall synthesis.
  • Emerging resistance mechanisms are a growing concern for fosfomycin efficacy.
  • Limited data exists on the precise prevalence of resistance across various pathogens.

Conclusions:

  • Understanding fosfomycin resistance mechanisms is crucial for effective antimicrobial stewardship.
  • Further research is needed to accurately determine the prevalence of fosfomycin resistance globally.
  • Addressing resistance is vital to preserve fosfomycin as a key therapeutic option.
Keywords:
FosfomycinFosfomycin–Trometamolantibioticresistanceurinary tract infections

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