Related Experiment Video

Updated: Feb 2, 2026

Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting
05:56

Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting

Published on: June 21, 2024

2.1K

Effect of prophylactic palonosetron and sugammadex on postoperative nausea and vomiting in patients undergoing

Hee Yong Kang1, Sung Wook Park, Sangho Lee

  • 1Department of Anesthesiology and Pain Medicine, College of Medicine, Kyung Hee University, Seoul, Korea.

Medicine
|November 16, 2018
PubMed

Insights

Prophylactic palonosetron and sugammadex significantly reduce postoperative nausea and vomiting (PONV) in microvascular decompression (MVD) patients. This combination therapy is key for managing PONV in these high-risk craniotomy cases.

Area of Science:

  • Anesthesiology
  • Neuroscience
  • Pharmacology

Background:

  • Microvascular decompression (MVD) surgery carries a high risk of postoperative nausea and vomiting (PONV).
  • Limited data exists on the efficacy of palonosetron and sugammadex for PONV prevention in MVD patients under propofol anesthesia.

Purpose of the Study:

  • To evaluate the effect of prophylactic palonosetron and sugammadex on PONV incidence in MVD patients.
  • To identify risk factors for PONV in this specific surgical population.

Main Methods:

  • Retrospective review of 274 adult MVD patients under propofol anesthesia.
  • Patients were grouped based on the use of sugammadex/pyridostigmine and prophylactic palonosetron.
  • PONV incidence and risk factors were analyzed.

Main Results:

  • Overall PONV incidence was 30.7% within 24 hours postoperatively.
  • The combination of palonosetron and sugammadex reduced PONV incidence to 19.3% compared to 37.2% without both agents.
  • Female sex was an independent risk factor for PONV (OR=2.62).

Conclusions:

  • Combined prophylactic palonosetron and sugammadex significantly reduce PONV in MVD patients under propofol anesthesia.
  • This combination therapy is associated with a lower incidence of PONV.
  • Female sex is a significant independent risk factor for PONV in this patient group.

More Related Videos

Microvascular Decompression: Salient Surgical Principles and Technical Nuances10:35

Microvascular Decompression: Salient Surgical Principles and Technical Nuances

Published on: July 5, 2011

47.3K
Author Spotlight: Alleviating Nausea and Vomiting in Pregnancy with Safe and Effective Auricular Acupuncture05:33

Author Spotlight: Alleviating Nausea and Vomiting in Pregnancy with Safe and Effective Auricular Acupuncture

Published on: August 4, 2023

2.3K

Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
783
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
668
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists01:29

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
884
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
622
Observational Studies01:11

Observational Studies

Observational studies are a type of analytical study where researchers observe events without any interventions. In other words, the researcher does not influence the response variable or the experiment's outcome.
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
11.1K
Pathophysiology of Vomiting01:22

Pathophysiology of Vomiting

Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through...
3.0K