Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Osteoarthritis.

D Hamerman1

  • 1Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY.

Orthopaedic Review
|April 1, 1988
PubMed
Summary
This summary is machine-generated.

Osteoarthritis (OA) is a common chronic disease affecting older adults. Understanding its complex evolution, involving cellular interactions and biomechanics, remains challenging, limiting effective treatment strategies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Osteoporosis and atherosclerosis: biological linkages and the emergence of dual-purpose therapies.

QJM : monthly journal of the Association of Physicians·2005
Same author

Evaluation of vertebral fractures on lateral chest radiographs of inner-city postmenopausal women.

Calcified tissue international·2003
Same author

Translating basic aging research into geriatric health care.

Experimental gerontology·2001
Same author

Considerations of osteoporosis prevention in an aging society.

Maturitas·2001
Same author

Emerging evidence for inflammation in conditions frequently affecting older adults: report of a symposium.

Journal of the American Geriatrics Society·1999
Same author

Toward an understanding of frailty.

Annals of internal medicine·1999
Same journal

Simple intraoperative traction system for acetabular fracture surgery.

Orthopaedic review·1994
Same journal

A 37-year-old man with left foot pain. Symptomatic accessory navicular synchondrosis.

Orthopaedic review·1994
Same journal

The use of somatosensory evoked potentials to prevent ischemic neural damage during preoperative embolization of a vascular renal metastasis.

Orthopaedic review·1994
Same journal

Comparison of axial T1 spin-echo and T1 fat-saturation magnetic resonance imaging techniques in the diagnosis of chondromalacia patellae.

Orthopaedic review·1994
Same journal

Scoliosis in Rett syndrome.

Orthopaedic review·1994
Same journal

On recycling in the operating room.

Orthopaedic review·1994
See all related articles

Area of Science:

  • Rheumatology
  • Orthopedics
  • Biochemistry
  • Biomechanics

Background:

  • Osteoarthritis (OA) is a prevalent chronic disease and a leading cause of rheumatic complaints in the elderly.
  • Current understanding of OA primarily views it as cartilage degeneration linked to aging.
  • Emerging concepts highlight cellular interactions, cartilage biochemistry, biomechanics, and pharmacology in OA.

Purpose of the Study:

  • To survey the current, albeit incomplete, knowledge of osteoarthritis (OA) in extremity joints.
  • To stimulate further exploration into the evolution of OA, particularly by orthopedic surgeons.
  • To address the difficulties in coherently understanding OA's progression and its underlying disease processes.

Main Methods:

Related Experiment Videos

  • Review of current literature and concepts in OA research.
  • Discussion of challenges in population studies, including reliance on physical inspection, pain complaints, and X-rays.
  • Consideration of biochemical and biomechanical factors, and opportunities for studying OA evolution in younger populations (e.g., post-menisceal injury).

    • Main Results:

    • Despite advancements, a comprehensive understanding of OA's evolutionary process remains elusive.
    • Current diagnostic methods like physical inspection and X-rays have limitations in accurately assessing OA, especially in population studies.
    • Access to joint samples for biochemical studies in younger demographics is limited, hindering research into accelerated OA progression.

    Conclusions:

    • The complex nature of osteoarthritis (OA) necessitates a multidisciplinary approach, integrating cellular, biochemical, and biomechanical perspectives.
    • Further research is crucial to elucidate the evolutionary pathways of OA, improving diagnostic accuracy and therapeutic interventions.
    • Orthopedic surgeons are encouraged to contribute to understanding OA's progression, given their significant role in joint health and surgical interventions.