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Updated: Feb 2, 2026

Noninvasive, High-throughput Determination of Sleep Duration in Rodents
Published on: April 18, 2018
Longitudinal Analysis of Sleep Duration and Cardiometabolic Risk in Young Children
Lesley Plumptre1, Laura N Anderson1,2, Yang Chen3
11 Child Health Evaluative Sciences, The Hospital for Sick Children , Toronto, Ontario, Canada .
Insights
Early childhood sleep duration did not impact overall cardiometabolic risk in later childhood. However, shorter sleep was linked to higher high-density lipoprotein (HDL) levels, warranting further investigation into sleep
Area of Science:
- Pediatric Health
- Sleep Science
- Cardiovascular Health
Background:
- Cardiometabolic risk (CMR) in children is a growing concern.
- Understanding early life factors influencing CMR is crucial for preventative strategies.
- Sleep duration is a modifiable behavior with potential links to child health outcomes.
Purpose of the Study:
- To investigate the association between early childhood sleep duration and cardiometabolic risk in later childhood.
- To examine the relationship between sleep duration and individual cardiometabolic factors, including BMI z-score.
- To assess the utility of a cardiometabolic risk cluster score in this cohort.
Main Methods:
- Prospective cohort study utilizing data from the TARGet Kids! network.
- Inclusion of 597 children with parent-reported sleep duration (12-36 months) and CMR factors (36-96 months).
- Multivariable linear regression analysis to determine associations, adjusting for covariates.
Main Results:
- Average sleep duration in early childhood was 11.8 hours, with 87% meeting recommendations.
- No significant association was found between early childhood sleep duration and the later childhood CMR cluster score.
- Shorter sleep duration in early childhood was associated with higher high-density lipoprotein (HDL) concentrations (adjusted β = -0.028, p = 0.009).
Conclusions:
- Early childhood sleep duration does not appear to be associated with overall cardiometabolic risk in later childhood.
- A potential association between shorter sleep duration and higher HDL levels in later childhood requires further investigation.
- Future research should consider sleep quality alongside sleep duration to fully understand its impact on cardiometabolic health.
Background:
The aim of this study is to determine if sleep duration in early childhood is associated with cardiometabolic risk (CMR) in later childhood as assessed by a CMR cluster score [sum of age- and sex-standardized z-scores of waist circumference (WC), systolic blood pressure, triglycerides, glucose, and (inverse) high-density lipoprotein (HDL)]. Secondary objectives included examining sleep duration and the individual CMR factors and BMI z-score.
Patients And Methods:
A prospective cohort study was conducted using data from the TARGet Kids! practice-based research network in Toronto, Canada. Children (n = 597) with parent-reported 24-hour sleep duration in early childhood (12-36 months) and a follow-up visit (36-96 months) with all five CMR factors were included in the analysis. Multivariable linear regression was used to assess the relationship between early childhood sleep duration and later childhood CMR, adjusting for relevant covariates.
Results:
Average 24-hour sleep duration in early childhood [mean age: 28.1 (6.6) months] was 11.8 (1.4) hours, with 87% meeting or exceeding total sleep recommendations for their age. Sleep duration in early childhood was not associated with the CMR cluster score in later childhood. Shorter sleep duration was associated with higher HDL concentrations [adjusted β = -0.028 (95% confidence interval: -0.049 to -0.007), p = 0.009].
Conclusions:
Further research is needed to determine if early childhood sleep duration is associated with HDL in later childhood. Future studies, which investigate sleep quality in addition to sleep duration, may be helpful.
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