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Crohn's disease beginning during pregnancy.

¹Department of Internal Medicine, University of Kansas Medical Center, Kansas City 66102.

Southern Medical Journal

|August 1, 1988

Summary

Pregnancy-onset Crohn's disease is rare and dangerous, with high complication rates and mortality for both mothers and infants. This condition, even with modern medicine, carries a poor prognosis similar to decades past.

Area of Science:

Gastroenterology
Obstetrics
Perinatology

Background:

Crohn's disease is a chronic inflammatory bowel disease.
Pregnancy-onset Crohn's disease is an exceptionally rare clinical presentation.
Limited data exists on the maternal and fetal outcomes for this specific condition.

Observation:

This report details the 11th documented case of Crohn's disease presenting initially during pregnancy.
Previous literature includes ten cases, highlighting significant morbidity and mortality.
The current case adds to the understanding of this rare syndrome's clinical course.

Findings:

The complication rate in pregnancy-onset Crohn's disease is notably high.
Among previously reported patients, 50% (5/10) required surgical intervention during pregnancy.

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Mortality rates are substantial, with 58% (7/12) of infants and 18% (2/11) of mothers in reported cases not surviving.

Implications:

The prognosis for Crohn's disease presenting during pregnancy remains poor, unchanged over the last 40 years.
This underscores the need for careful management and monitoring of pregnant patients with inflammatory bowel disease.
Further research is warranted to improve outcomes for this high-risk obstetric and gastrointestinal condition.