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Cyclophilin, a primary molecular target for cyclosporine. Structural and functional implications

M W Harding1, R E Handschumacher

  • 1Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510.

Transplantation
|August 1, 1988
PubMed
Summary

Cyclophilin (CYP) is identified as the primary cellular receptor for cyclosporine (CsA), a crucial immunosuppressant. This finding implicates CYP in regulating T and B cell activation and cellular signaling pathways.

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