Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Modern neurosyphilis--a critical analysis.

The Western Journal of Medicine

|July 1, 1988

Summary

This summary is machine-generated.

Neurosyphilis diagnosis and treatment remain complex. Current evidence suggests cerebrospinal fluid (CSF) VDRL is optimal, pleocytosis indicates activity, and prolonged penicillin therapy is necessary, with no clear link to HIV acceleration.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Transcranial focused ultrasound for the treatment of tremor: A preliminary case series.

Brain stimulation·2023

Same author

TC-5619: an alpha7 neuronal nicotinic receptor-selective agonist that demonstrates efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia.

Biochemical pharmacology·2009

Same author

Continuous ICU EEG monitoring.

Supplements to Clinical neurophysiology·2003

Same author

Making the transition: the role of helical CT in the evaluation of potentially acute thoracic aortic injuries.

AJR. American journal of roentgenology·2001

Same author

Nonconvulsive status epilepticus in acute brain injury.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·1999

Same author

Continuous EEG monitoring in the neuroscience intensive care unit and emergency department.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·1999

Same journal

Does daily use of sunscreen or beta-carotene supplements prevent skin cancer in healthy adults?

The Western journal of medicine·2008

Same journal

[Not Available].

The Western journal of medicine·2008

Same journal

[Not Available].

The Western journal of medicine·2008

Same journal

[Not Available].

The Western journal of medicine·2008

Same journal

[Not Available].

The Western journal of medicine·2008

Same journal

[Not Available].

The Western journal of medicine·2008

See all related articles

Area of Science:

Neurology
Infectious Diseases
Clinical Medicine

Background:

Neurosyphilis presents diagnostic and therapeutic challenges for physicians.
Ongoing debates surround serologic tests, cerebrospinal fluid (CSF) findings, diagnostic criteria, and treatment protocols.
Co-infection with human immunodeficiency virus (HIV) has raised concerns about potential neurosyphilis resurgence.

Purpose of the Study:

To critically analyze the evidence concerning neurosyphilis diagnosis, interpretation of CSF abnormalities, diagnostic criteria, and treatment.
To evaluate the impact of concurrent HIV infection on neurosyphilis progression and treatment response.

Main Methods:

Critical analysis of existing scientific evidence and literature.
Review of data regarding serologic tests and cerebrospinal fluid (CSF) analysis in neurosyphilis.

Related Experiment Videos

Examination of treatment regimens and outcomes, including cases with HIV co-infection.

Main Results:

The cerebrospinal fluid (CSF) Venereal Disease Research Laboratory (VDRL) test is identified as the most appropriate diagnostic tool.
Pleocytosis in CSF is the sole reliable indicator of active neurosyphilis.
Current diagnostic criteria may not sufficiently differentiate neurosyphilis from other conditions.
Prolonged parenteral penicillin administration remains the standard treatment, with no demonstrably superior alternative.
Available data do not substantiate claims of accelerated or treatment-resistant neurosyphilis in HIV-infected patients.

Conclusions:

The CSF VDRL test and monitoring CSF pleocytosis are crucial for diagnosing and assessing neurosyphilis activity.
Standard diagnostic criteria require refinement to improve specificity.
Extended parenteral penicillin therapy is essential for effective neurosyphilis treatment.
Concurrent HIV infection does not appear to significantly alter the course or resistance of neurosyphilis based on current evidence.