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Evolving conceptualizations of cocaine dependence.

F H Gawin1, H D Kleber

  • 1Yale University School of Medicine, New Haven, Connecticut.

The Yale Journal of Biology and Medicine
|March 1, 1988
PubMed
Summary

Cocaine dependence was once dismissed but is now a major public health concern. Research reveals unique cocaine abuse patterns and neurophysiological changes, leading to new pharmacological treatments.

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Area of Science:

  • Neuroscience
  • Public Health
  • Pharmacology

Background:

  • Cocaine's perceived inability to cause dependence has shifted dramatically since 1980.
  • Once thought to lack a withdrawal syndrome, clinical evidence now highlights unique cocaine abuse and withdrawal patterns.

Purpose of the Study:

  • To review the evolving understanding of cocaine dependence.
  • To explore neurophysiological alterations associated with chronic cocaine abuse.
  • To discuss emerging pharmacological treatments for cocaine abuse.

Main Methods:

  • Review of clinical investigations and pre-clinical research.
  • Analysis of neurophysiological changes in central nervous system pleasure pathways.
  • Examination of pharmacological treatment applications.

Main Results:

  • Cocaine abuse exhibits distinct patterns differing from other drugs.
  • Chronic cocaine use induces neurophysiological alterations affecting pleasure regulation.
  • Experimental pharmacological treatments show promise for cocaine abuse.

Conclusions:

  • Cocaine dependence is a significant public health issue with unique characteristics.
  • Neuroscientific insights into cocaine's effects are driving treatment innovation.
  • Pharmacological interventions offer a promising avenue for managing cocaine abuse.

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