Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Vaccinations

Vaccinations

What is Genetic Engineering?

What is Genetic Engineering?

Cancer Vaccines

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

Target Cell Response to Hormones

Target Cell Response to Hormones

Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...

Buffer Effectiveness

Buffer Effectiveness

Buffer solutions do not have an unlimited capacity to keep the pH relatively constant . Instead, the ability of a buffer solution to resist changes in pH relies on the presence of appreciable amounts of its conjugate weak acid-base pair. When enough strong acid or base is added to substantially lower the concentration of either member of the buffer pair, the buffering action within the solution is compromised.
The buffer capacity is the amount of acid or base that can be added to a given volume...

Framing Effects

Framing Effects

Information is everywhere and its presentation—such as how and when items are presented—can impact our perceptions and decisions surrounding the info. This broad concept umbrellas framing effects—influences that occur due to the way information is framed in its appearance, whether it’s purely the order or the specific wording of a message. Let’s take a look at numerous ways in which two versions of something can objectively say the same thing, yet we respond in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Development of 2-deoxy-d-ribose and zinc oxide loaded microneedle array patches of chitosan and PVA to stimulate angiogenesis and reduce infection and promote wound healing.

Biomaterials advances·2026

Same author

Unlocking the potential of lipid-based nanoparticles for intranasal drug delivery in Parkinson's disease.

International journal of pharmaceutics·2026

Same author

Recent advances in engineering approaches for delivery of mRNA-based therapeutics.

Biomaterials advances·2026

Same author

CardioTabNet: a novel hybrid transformer model for heart disease prediction using tabular medical data.

Health information science and systems·2025

Same author

Multi-class subarachnoid hemorrhage severity prediction: addressing challenges in predicting rare outcomes.

Neurosurgical review·2025

Same author

Targeting CDKs in cancer therapy: advances in PROTACs and molecular glues.

NPJ precision oncology·2025

Search research articles

Related Experiment Video

Updated: Feb 2, 2026

Accessing the Cytotoxicity and Cell Response to Biomaterials

Accessing the Cytotoxicity and Cell Response to Biomaterials

Published on: July 8, 2021

M cell targeting engineered biomaterials for effective vaccination.

Mohammad Ariful Islam¹, Jannatul Firdous², Abu Zayed Md Badruddoza³

¹Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

|November 16, 2018

Summary

This review explores engineered biomaterials for mucosal vaccines that target microfold (M) cells. These advanced delivery systems aim to enhance vaccine efficacy and overcome current challenges in M cell targeting for next-generation therapeutics.

Keywords:

Antibody response Engineered materials M cell Mucosa-associated lymphoid tissues Mucosal vaccination Peyer's patch Targeted delivery systems

More Related Videos

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates

Published on: May 9, 2025

Growth of Human and Sheep Corneal Endothelial Cell Layers on Biomaterial Membranes

Growth of Human and Sheep Corneal Endothelial Cell Layers on Biomaterial Membranes

Published on: February 6, 2020

Related Experiment Videos

Last Updated: Feb 2, 2026

Accessing the Cytotoxicity and Cell Response to Biomaterials

Accessing the Cytotoxicity and Cell Response to Biomaterials

Published on: July 8, 2021

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates

Published on: May 9, 2025

Growth of Human and Sheep Corneal Endothelial Cell Layers on Biomaterial Membranes

Growth of Human and Sheep Corneal Endothelial Cell Layers on Biomaterial Membranes

Published on: February 6, 2020

Area of Science:

Biomaterials Science
Immunology
Vaccinology

Background:

Vaccines are crucial medical interventions, with mucosal vaccines showing significant therapeutic potential.
Targeting microfold (M) cells is essential for effective mucosal vaccination strategies.
Current literature lacks comprehensive reviews on M cell targeting for vaccine delivery.

Purpose of the Study:

To review engineered materials for vaccine delivery platforms targeting M cells.
To discuss potential M cell targeting strategies and challenges.
To explore biomaterials and delivery technologies for next-generation mucosal vaccines.

Main Methods:

Literature review focusing on engineered materials for M cell targeting.
Analysis of current challenges and limitations in M cell targeting for vaccines.
Exploration of biomaterials engineering and natural/synthetic delivery technologies.

Main Results:

Engineered materials offer promising platforms for M cell targeting in mucosal vaccines.
Various strategies and technologies can overcome existing challenges in M cell targeting.
Biomaterials engineering presents novel approaches for vaccine delivery.

Conclusions:

Targeting M cells with engineered delivery systems is key for effective mucosal vaccines.
Biomaterials and advanced delivery technologies hold significant potential for next-generation vaccines.
Further research and development are needed for manufacturing and regulatory approval.