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A Revised Surgical Approach to Induce Endolymphatic Hydrops in the Guinea Pig
Published on: June 4, 2020
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Gentamicin delivery to the inner ear: Does endolymphatic hydrops matter?
Pedro Marques1,2, Maoli Duan3,4, Nicolas Perez-Fernandez5
1Department of Otorhinolaryngology, S.João Hospital Centre, Porto, Portugal.
Plos One
|November 16, 2018
Summary
Endolymphatic hydrops negatively impacts gentamicin delivery to the inner ear via middle ear application. This finding is crucial for optimizing Ménière
Area of Science:
- Ototoxicology
- Inner Ear Physiology
- Pharmacokinetics
Background:
- Middle ear gentamicin application is a standard treatment for Ménière's disease.
- Endolymphatic hydrops is a characteristic feature of Ménière's disease.
- The efficacy of gentamicin delivery may be influenced by inner ear conditions.
Purpose of the Study:
- To investigate the effect of endolymphatic hydrops on gentamicin concentration in the inner ear.
- To assess the correlation between the degree of endolymphatic hydrops and perilymph gentamicin levels.
Main Methods:
- An animal model of endolymphatic hydrops was created in guinea pigs.
- Gentamicin was administered via round window niche or transtympanic injection.
- Perilymph gentamicin concentrations and hydrops severity were measured.
Main Results:
- Animals with endolymphatic hydrops showed significantly lower perilymph gentamicin concentrations.
- A negative correlation was found between hydrops severity and gentamicin levels.
- This effect was observed for both administration routes.
Conclusions:
- Endolymphatic hydrops impairs gentamicin's inner ear penetration.
- Treatment strategies for Ménière's disease may need to account for hydrops-related delivery changes.
- Further research is needed to optimize gentamicin delivery in Ménière's disease.
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