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[Correlation between serum CD147 and carotid intraplaque hemorrhage]
1Department of Vascular Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China.
Zhonghua Yi Xue Za Zhi
|November 16, 2018
Summary
Intraplaque hemorrhage (IPH) is linked to higher serum CD147 levels. Serum CD147 shows diagnostic value for carotid IPH, particularly in patients not using statins.
Area of Science:
- Cardiovascular Research
- Neurology
- Biomarker Discovery
Background:
- Intraplaque hemorrhage (IPH) is a critical factor in ischemic stroke pathogenesis.
- Identifying reliable biomarkers for IPH is crucial for risk stratification and management.
Purpose of the Study:
- To investigate the association between carotid intraplaque hemorrhage (IPH) and serum CD147 levels.
- To evaluate CD147 as a potential serum biomarker for carotid IPH.
Main Methods:
- Serum samples from 68 patients with carotid artery stenosis were analyzed.
- 3.0T MRI with an 8-channel surface coil was used for carotid artery imaging.
- Plaque components (lipid, IPH, calcification, fibrous cap) were analyzed, and correlations with serum CD147 were assessed.
Main Results:
- Serum CD147 levels were significantly higher in patients with IPH compared to those without (P=0.04).
- Serum CD147 showed a strong diagnostic value for carotid IPH in patients not using statins (AUC=0.81).
- Serum CD147 levels were lower in statin users and positively correlated with total cholesterol and LDL.
Conclusions:
- Serum CD147 may serve as a potential biomarker for intraplaque hemorrhage.
- CD147 demonstrates good diagnostic value for carotid IPH, especially in specific patient populations like those not on statin therapy.
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