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A Murine Model of Subarachnoid Hemorrhage
Published on: November 21, 2013
[Correlation between serum CD147 and carotid intraplaque hemorrhage]
1Department of Vascular Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China.
Insights
Intraplaque hemorrhage (IPH) is linked to higher serum CD147 levels. Serum CD147 shows diagnostic value for carotid IPH, particularly in patients not using statins.
Area of Science:
- Cardiovascular Research
- Neurology
- Biomarker Discovery
Background:
- Intraplaque hemorrhage (IPH) is a critical factor in ischemic stroke pathogenesis.
- Identifying reliable biomarkers for IPH is crucial for risk stratification and management.
Purpose of the Study:
- To investigate the association between carotid intraplaque hemorrhage (IPH) and serum CD147 levels.
- To evaluate CD147 as a potential serum biomarker for carotid IPH.
Main Methods:
- Serum samples from 68 patients with carotid artery stenosis were analyzed.
- 3.0T MRI with an 8-channel surface coil was used for carotid artery imaging.
- Plaque components (lipid, IPH, calcification, fibrous cap) were analyzed, and correlations with serum CD147 were assessed.
Main Results:
- Serum CD147 levels were significantly higher in patients with IPH compared to those without (P=0.04).
- Serum CD147 showed a strong diagnostic value for carotid IPH in patients not using statins (AUC=0.81).
- Serum CD147 levels were lower in statin users and positively correlated with total cholesterol and LDL.
Conclusions:
- Serum CD147 may serve as a potential biomarker for intraplaque hemorrhage.
- CD147 demonstrates good diagnostic value for carotid IPH, especially in specific patient populations like those not on statin therapy.
Abstract:
Objective: Intraplaque hemorrhage (IPH) is one of the most important causes of ischemic stroke. The purpose of this study was to explore the association between carotid IPH and CD147, which may be the serum marker related to IPH. Methods: Serum samples were collected from 68 patients with carotid artery stenosis from April to September 2004. 3.0T MRI with the 8 channel surface coil was used to scan carotid artery. Images was processed by MRI-PlaqueView. The integrity of lipid, IPH, calcified components and fibrous cap in the plaque was analysed qualitatively and quantitatively. The correlation and difference analysis among serum CD147 and plaque components were carried out. Results: Serum CD147 level in IPH positive was higher than that in IPH negative, 5 510.1 vs 4 648.0 (P=0.04). There was no significant correlation among serum CD147 and the quantitative parameters of lipid, IPH and calcification in carotid plaque and fibrous cap rupture. Serum CD147 in patients using statins was lower than that in patients not using statins, 4 914.0 vs 5 926.7 (P<0.01). Serum total cholesterol and LDL were positively correlated with serum CD147. In patients without statin, serum CD147 had a better diagnostic value for carotid IPH (AUC=0.81, P=0.04, 95% CI 0.62-0.99). Conclusion: Serum CD147 would probably be one biomarker of IPH and shows good diagnostic value of carotid IPH in the specific population.
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