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Related Experiment Videos

A Molecular Imaging "Skin A Time-resolving Intraoperative Imager for Microscopic Residual Cancer Detection Using

Hossein Najafiaghdam, P Papageorgiou, Nicole A Torquato

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |November 17, 2018
    PubMed
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    This study introduces an optics-free molecular imaging "skin" for enhanced cancer surgery. This technology detects microscopic residual cancer cells, improving surgical precision and reducing recurrence risk.

    Area of Science:

    • Biomedical Engineering
    • Medical Imaging
    • Nanotechnology

    Background:

    • Microscopic residual cancer cells increase recurrence risk after surgery.
    • Current intraoperative imaging lacks sensitivity and maneuverability for microscopic disease.
    • Conventional imagers are limited by optics, size, and autofluorescence.

    Purpose of the Study:

    • To develop a novel, optics-free molecular imaging system for intraoperative detection of residual cancer.
    • To overcome limitations of conventional fluorescent imaging in surgical settings.
    • To enable visualization of microscopic disease for improved cancer treatment outcomes.

    Main Methods:

    • An optics-free molecular imaging
    • skin
    • utilizing a thin CMOS contact imager.

    Related Experiment Videos

  • Integration of upconverting nanoparticles (UCNP) with long emission lifetimes.
  • Time-domain imaging approach with infrared illumination for deep tissue penetration and autofluorescence elimination.

    • Main Results:

    • Successful visualization of UCNPs at clinically compatible fluences (W/cm2).
    • Demonstrated microscopic sensitivity for detecting residual cancer cells.
    • Elimination of autofluorescence and deep tissue penetration achieved.

    Conclusions:

    • The developed optics-free imaging system offers high sensitivity for microscopic residual cancer detection.
    • This technology enhances intraoperative visualization, aiding surgeons in complete tumor removal.
    • Paves the way for precision post-operative radiation therapy and improved cancer patient outcomes.