Spiral Folded Adhesive Plaster Optimization for Laparoscopic Surgery.

Area of Science:

• Biomaterials Science
• Surgical Innovation
• Medical Device Development

Background:

• Laparoscopic surgery offers minimally invasive benefits but presents technical challenges for surgeons, particularly in suturing.
• Current suturing techniques in minimally invasive procedures require high dexterity and can be time-consuming.
• There is a need for alternative wound closure methods that are less technically demanding and maintain effective sealing.

Purpose of the Study:

• To develop and optimize an adhesive plaster as an alternative to suturing in laparoscopic surgery.
• To determine the optimal material composition and structural design for a thermally cross-linked gelatin film plaster.
• To evaluate the performance characteristics of the optimized plaster for wound sealing applications.

Main Methods:

• Fabrication of adhesive plasters using thermally cross-linked gelatin films in a spiral fold structure.
• Experimental evaluation of plaster properties including expansion rate, expansion tension, peeling force, and sealing pressure.
• Optimization of gelatin volume, concentration, and film diameter using the response surface method.

Main Results:

• The optimized plaster formulation consists of 10 mL gelatin volume, 4 wt % gelatin concentration, and a 75 mm film diameter.
• The optimized plaster demonstrated sufficient expansion, tackiness, and sealing properties for surgical incision closure.
• Response surface methodology effectively identified optimal parameters for the gelatin plaster.

Conclusions:

• The developed spiral-folded adhesive plaster using thermally cross-linked gelatin is a viable alternative to traditional suturing in laparoscopic surgery.
• The optimized plaster meets key performance criteria for effective wound sealing in minimally invasive procedures.
• Further research can explore clinical applications and long-term efficacy of this novel wound closure device.