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    Researchers developed a new implantable sensor to accurately measure bladder fluid volume without a catheter. This innovation aids in understanding bladder control and developing treatments for incontinence.

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    Area of Science:

    • Biomedical Engineering
    • Neuroscience
    • Urology

    Background:

    • Understanding the neural control of the lower urinary tract (LUT) is crucial for developing effective treatments for conditions like incontinence.
    • Current methods for monitoring bladder function can be invasive or limited in scope.
    • New research tools are needed for chronic neurophysiological studies and ambulatory urodynamics.

    Purpose of the Study:

    • To design, prototype, and validate a novel sensing mechanism for a catheter-free fluid volume estimation system.
    • To enable chronic neurophysiological studies and ambulatory urodynamics of the lower urinary tract.
    • To develop a minimally invasive device for real-time bladder volume measurement.

    Main Methods:

    • Developed a system with two stimulation electrodes, one sensing anode, and a microcontroller for control and recording.
    • Designed a small, implantable device for surgical placement within the bladder lumen.
    • Conducted benchtop evaluations using simulated bladder conditions to assess volume estimation accuracy.

    Main Results:

    • The implantable device demonstrated minimal inhibition of bladder function and no inflicted trauma.
    • The conductance-sensing system predicted intravesical fluid volume with a mean error of less than 5 mL below 40 mL.
    • The system achieved a worst-case mean error of 13 mL near full-scale bladder volume.

    Conclusions:

    • Conductance-based volume sensing is a feasible method for real-time measurement of urinary bladder volume.
    • The developed system offers a promising tool for advancing the understanding of bladder neurophysiology.
    • This technology could pave the way for new treatments and neuroprosthetics for urinary incontinence.