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Related Concept Videos

Metallic Solids02:37

Metallic Solids

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Metallic solids such as crystals of copper, aluminum, and iron are formed by metal atoms. The structure of metallic crystals is often described as a uniform distribution of atomic nuclei within a “sea” of delocalized electrons. The atoms within such a metallic solid are held together by a unique force known as metallic bonding that gives rise to many useful and varied bulk properties.
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
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Structures of Solids02:22

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Solids in which the atoms, ions, or molecules are arranged in a definite repeating pattern are known as crystalline solids. Metals and ionic compounds typically form ordered, crystalline solids. A crystalline solid has a precise melting temperature because each atom or molecule of the same type is held in place with the same forces or energy. Amorphous solids or non-crystalline solids (or, sometimes, glasses) which lack an ordered internal structure and are randomly arranged. Substances that...
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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
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Network Covalent Solids02:18

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Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
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Related Experiment Video

Updated: Feb 2, 2026

Monitoring Protein Adsorption with Solid-state Nanopores
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A Novel Diagnostic System for Infectious Diseases Using Solid-State Nanopore Devices.

T Miyagawa, S Hongo, N Nakamura

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |November 17, 2018
    PubMed
    Summary
    This summary is machine-generated.

    This study introduces a novel nanopore diagnostic system for virus detection. It combines specific probe capture and electrochemical release for accurate virus subtype identification.

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    Sequencing of mRNA from Whole Blood using Nanopore Sequencing
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    Area of Science:

    • Biotechnology
    • Nanotechnology
    • Infectious Disease Diagnostics

    Background:

    • Nanopore devices offer single-virus counting capabilities.
    • Current nanopore technology faces challenges in distinguishing virus subtypes.
    • Advanced diagnostic methods are needed for precise viral identification.

    Purpose of the Study:

    • To develop a novel diagnostic system for specific virus subtype recognition using nanopore technology.
    • To enhance the accuracy of nanopore-based viral detection through a multi-step procedure.
    • To demonstrate the applicability of the proposed system for various infectious agents.

    Main Methods:

    • A three-step procedure: specific probe-based virus capture, electrochemical release, and nanopore detection.
    • Proof-of-concept validation using model particles (avidin-modified fluorescent particles) and probes (biotin-modified alkane thiol).
    • Application testing with human influenza viruses (H1N1) and specific sugar chain probes.

    Main Results:

    • Successfully demonstrated capture and electrochemical release of model particles using specific probes.
    • Confirmed detection of released particles by nanopore devices.
    • Validated the system's effectiveness with human influenza viruses and targeted probes.

    Conclusions:

    • The proposed diagnostic system enables specific virus recognition and detection via nanopore analysis.
    • The method is adaptable for detecting various infectious diseases by modifying capture probes.
    • This approach represents a significant advancement in high-resolution viral diagnostics.