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A Multi-site Heart Pacing Study Using Wirelessly Powered Leadless Pacemakers
Summary
We developed an energy-efficient, millimeter-scale pacemaker and wireless power system. This system enabled simultaneous, electromechanical heart pacing in two separate models using a single transmitter.
Area of Science:
- Biomedical Engineering
- Cardiovascular Research
- Wireless Power Transfer
Background:
- Traditional pacemakers face limitations in energy efficiency and distributed pacing capabilities.
- Millimeter-scale devices and efficient wireless power transfer are crucial for advanced cardiac therapies.
Purpose of the Study:
- To develop and demonstrate an energy-efficient, millimeter-scale pacemaker system for multi-site cardiac pacing.
- To evaluate the feasibility of simultaneous, wireless, electromechanical coupling of multiple hearts.
Main Methods:
- Designed a switched capacitor-based millimeter-scale pacemaker (5 mm ×7.5 mm).
- Developed a multi-receiver wireless energy transfer system operating at ~200 MHz.
- Conducted a proof-of-concept study using two beating Langendorff rodent heart models.
Main Results:
- Two millimeter-scale pacemakers successfully paced two separate Langendorff hearts simultaneously.
- A single transmitter (20-30 cm distance) enabled wireless energy transfer and pacing for both hearts.
- Demonstrated electromechanical coupling between the two paced hearts.
Conclusions:
- The developed system shows promise for energy-efficient, distributed cardiac pacing.
- This technology offers a potential solution for advanced cardiac resynchronization therapies.
- Highlights the feasibility of simultaneous multi-site heart pacing via wireless power transfer.
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