InSilc: 3D Reconstruction and plaque characterization tool

Area of Science:

• Biomedical Engineering
• Cardiovascular Research
• Medical Imaging

Background:

• Coronary artery disease (CAD) is a major global health concern, with atherosclerosis being a primary contributing factor.
• Drug-eluting bioresorbable vascular scaffolds (BVS) represent a promising therapeutic strategy for CAD management.
• Current assessment methods for BVS performance can be limited in scope and scalability.

Purpose of the Study:

• To present the architecture of the InSilc in silico clinical trial (ISCT) platform.
• To highlight the 3D reconstruction and plaque characterization tool within the InSilc platform.
• To demonstrate the platform's capability for large-scale clinical trial assessment of BVS.

Main Methods:

• Development of an InSilc ISCT platform integrating multiple modeling modules (Mechanical, Deployment, Fluid Dynamics, Myocardial Perfusion, Drug-delivery, Degradation).
• Utilization of a 3D reconstruction and plaque characterization tool requiring patient-specific arterial segments and BVS designs.
• Implementation of diverse medical image processing workflows with minimal user intervention.

Main Results:

• The InSilc platform architecture enables comprehensive assessment of drug-eluting BVS.
• The 3D reconstruction and plaque characterization tool facilitates the integration of patient-specific data.
• The platform is designed for efficient use in large-scale clinical trials, minimizing user input.

Conclusions:

• The InSilc platform offers a robust in silico approach for evaluating drug-eluting BVS.
• The 3D reconstruction tool is crucial for personalizing BVS assessment.
• This platform has the potential to significantly advance the development and clinical application of BVS for CAD treatment.