Related Experiment Video

Updated: Feb 2, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

4.3K

Modeling Cardiac Hemodynamic Response During Exercise in Health and Hypertrophic Cardiomyopathy

I Farro, C R Arbeitman, L J Cymberknop

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |November 17, 2018
    PubMed

    Insights

    Hypertrophic cardiomyopathy (HCM) patients exhibit reduced cardiac output during exercise compared to healthy individuals. A sigmoidal model effectively characterized these hemodynamic differences, aiding in understanding HCM exercise response.

    Area of Science:

    • Cardiology
    • Physiology
    • Biomedical Engineering

    Background:

    • Hypertrophic cardiomyopathy (HCM) is characterized by left ventricular outflow tract abnormalities and tissue changes.
    • Exercise testing is crucial for evaluating HCM and guiding treatment strategies.
    • Understanding hemodynamic alterations during exercise in HCM is vital.

    Purpose of the Study:

    • To model and compare hemodynamic alterations during exercise in healthy individuals and HCM patients using noninvasive methods.
    • To quantitatively assess cardiac output (CO) dynamics in different groups.

    Main Methods:

    • Assessed cardiac output (CO), heart rate (HR), arterial blood pressure (ABP), and Total Peripheral Resistance (TPR) during exercise.
    • Employed a curve-fitting approach using a sigmoidal model for quantitative CO profile comparison.

    Main Results:

    • HCM patients demonstrated reduced peak exercise cardiac output compared to controls.
    • Higher peripheral resistance was observed in HCM patients during exercise.
    • Healthy individuals showed a faster maximum rate of CO recovery than HCM patients.

    Conclusions:

    • The sigmoidal model proved effective in characterizing cardiac output dynamics for both healthy and HCM groups.
    • This modeling approach aids in differentiating exercise hemodynamics in HCM.
    • Noninvasive hemodynamic assessment during exercise is valuable for HCM evaluation.
    Abstract

    More Related Videos

    Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model06:22

    Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

    Published on: November 29, 2024

    1.5K
    Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training07:40

    Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training

    Published on: October 10, 2019

    7.8K

    Related Concept Videos

    Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

    Cardiomyopathy III: Hypertrophic Cardiomyopathy

    Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
    490
    Exercise and Cardiac Output01:17

    Exercise and Cardiac Output

    Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
    Sustained exercise increases the muscles' oxygen demand, which can be...
    2.0K
    Exercise and Cardiovascular Response01:20

    Exercise and Cardiovascular Response

    Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
    Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
    4.5K
    Cardiomyopathy II: Dilated Cardiomyopathy01:30

    Cardiomyopathy II: Dilated Cardiomyopathy

    Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
    568
    Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

    Cardiomyopathy IV: Restrictive Cardiomyopathy

    Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
    538
    Models of Health Promotion and Illness Prevention I01:25

    Models of Health Promotion and Illness Prevention I

    A model is a theoretical way to understand a concept or an idea. Models can overcome barriers to health regardless of diverse economic and cultural backgrounds. In addition, models make the task easier by providing different ways to approach complex issues. There are two major health promotion models: the health belief model and the health promotion model.
    The health belief model (HBM) attempts to predict health-related behavior in specific belief patterns. According to the HBM, a person's...
    2.8K