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    Summary
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    A novel microfluidic device reduces blood coagulation in implants by separating blood cells using curved channels. This extends medical device lifetime by minimizing clot formation without external power.

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    Area of Science:

    • Biomedical Engineering
    • Fluid Dynamics

    Background:

    • Blood coagulation within implanted medical devices is a critical issue limiting device longevity.
    • Current solutions often require external power sources or complex mechanisms.

    Purpose of the Study:

    • To develop a passive microfluidic device for blood separation to mitigate coagulation in implants.
    • To investigate the efficacy of curved and branched channels in reducing blood cell concentration.

    Main Methods:

    • A microfluidic device with curved and branched channels was designed and fabricated.
    • Centrifugal forces generated by curved flow were utilized for blood separation at bifurcations.
    • Experiments were conducted using human whole blood with varying hematocrit levels over seven days on titanium foil.

    Main Results:

    • The device successfully separated blood into cell-rich and cell-poor streams, reducing overall blood cell concentration.
    • Lower blood cell concentrations demonstrated reduced coagulability.
    • Device performance was found to be primarily influenced by flow rate and channel curvature.

    Conclusions:

    • The proposed passive microfluidic device effectively reduces blood cell concentration, thereby mitigating coagulation and extending the lifespan of implanted medical devices.
    • The device operates solely on blood pressure, eliminating the need for external power sources or pumps.